ArticleInternational journal of preventive medicine2013
Efficacy of Co-administration of Garlic Extract and Metformin for Prevention of Gentamicin-Renal Toxicity in Wistar Rats: A Biochemical Study.
Article in International journal of preventive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Protective Role and Mechanism of Action of Garlic in Organ Ischemia-reperfusion Injury: Where do we Stand?Current medicinal chemistry · 2026Review
- The Synergistic Effects of the Combination of L-Carnitine and Lycopene on the Lycopene Bioavailability and Duodenal Health of Roosters.Animals : an open access journal from MDPI · 2023Article
- Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats.Renal failure · 2017Article
- Diallyl Trisulfide Inhibits Growth of NCI-H460International journal of biological sciences · 2017Article
- Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications.Diabetology & metabolic syndrome · 2017Review
- The protective effect of hydro-alcoholic extract of mangrove (Journal of nephropathology · 2016Article
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.Jundishapur journal of microbiology · 2015Review
- Antioxidant Activity and Teratogenicity Evaluation of Lawsonia Inermis in BALB/c Mice.Journal of clinical and diagnostic research : JCDR · 2015Article
- New concepts in nutraceuticals as alternative for pharmaceuticals.International journal of preventive medicine · 2014Review
- Lack of nephroprotective efficacy of althaea officinalis flower extract against gentamicin renal toxicity in male rats.International journal of preventive medicine · 2014Article
- Teucrium polium: Liver and kidney effects.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Ameliorative effect of melatonin against contrast media induced renal tubular cell injury.Pakistan journal of medical sciences · 2014Article
- Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice.Parasite (Paris, France) · 2014Article
- Oxidative stress and aging prevention.International journal of preventive medicine · 2013Article
- Comment on: preventive effect of Teucrium polium on learning and memory deficits in diabetic rats.Medical science monitor basic research · 2013Article
- Comment on: The Protective Role of Silymarin and Deferoxamine Against Iron Dextran-Induced Renal Iron Deposition in Male Rats.International journal of preventive medicine · 2013Article
- Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: New concepts.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2013Article
- Renoprotective effects of metformin.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- Commentary on: Effects of Cinnamon Consumption on Glycemic Status, Lipid Profile and Body Composition in Type 2 Diabetic Patients.International journal of preventive medicine · 2013Article
- Combination of metformin with other antioxidants may increase its renoprotective efficacy.Journal of renal injury prevention · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGentamicin (GM) nephrotoxicity has been related to oxidative stress. Garlic and metformin (MF) have anti-oxadant activity and therefore, this study was aimed to evaluate the preventive and curative effects of garlic, MF and their combination on GM indeced tubular toxicity in Wistar rats.
methodsIn a pre-clinical study, 70 male Wistar rats were randomly designated into 7 groups of 10 and treated as follows: Group 1: Received saline for 20 days. Group 2: Were injected 100 mg/kg/d of GM intraperitoneally (ip), for 10 days and saline for 10 more days. Group 3: Received GM for 10 days then 20 mg/kg garlic ip for the next 10 days. Group 4: Received GM for 10 days and MF (100 mg/kg) orally for the next 10 days. Group 5: Received GM for 10 days and a combination of MF and garlic for the next 10 days (100 and 20 mg/kg, respectively). Group 6: The same as group 5but with half-doses of MF and Garlic. Group 7: Received GM for 10 days together with a combination ofMF and garlic. On 20(th) day of the experiment the serum blood urea nitrogen (BUN) and creatinine (Cr) were measured and compared in different groups.
resultsGM injection significantly increased the serum BUN and Cr (P < 0.05). Administration of MF, garlic or their combination with or after injection of GM (high doses) could atenuate BUN and Cr.
conclusionsThe results indicate that MF and garlic or their combination have curative and protective activity against GM nephrotoxicity.
Indexed as
Identifiers
23626881PMC3634163W2125859285What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.