ArticlePloS one2013
Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Preterm birth and birth weight extremes are associated with periodontal disease and tooth loss in the ARIC study.Scientific reports · 2026Article
- Low birth weight, DNA methylation patterns in cord blood, and inflammation at birth.Translational pediatrics · 2026Article
- NETosis inhibitory activity of LBW newborns' cord blood plasma reverses lupus-associated immunopathology.Frontiers in immunology · 2026Article
- Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life.Cytokine · 2021Article
- Article
- Transcriptome Differences Suggest Novel Mechanisms for Intrauterine Growth Restriction Mediated Dysfunction in Small Intestine of Neonatal Piglets.Frontiers in physiology · 2020Article
- S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation.Frontiers in immunology · 2020Review
- Identification of Differentially Expressed Hematopoiesis-associated Genes in Term Low Birth Weight Newborns by Systems Genomics Approach.Current genomics · 2019Article
- Current Understanding of Innate Immune Cell Dysfunction in Childhood Undernutrition.Frontiers in immunology · 2019Review
- Impact of Timing of Antiretroviral Treatment and Birth Weight on Mother-to-Child Human Immunodeficiency Virus Transmission: Findings From an 18-Month Prospective Cohort of a Nationally Representative Sample of Mother-Infant Pairs During the Transition From Option A to Option B+ in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- S100-alarmin-induced innate immune programming protects newborn infants from sepsis.Nature immunology · 2017Article
- Reduced PICD in Monocytes Mounts Altered Neonate Immune Response to Candida albicans.PloS one · 2016Article
- Antimicrobial Proteins and Peptides in Early Life: Ontogeny and Translational Opportunities.Frontiers in immunology · 2016Review
- Genome wide screening of candidate genes for improving piglet birth weight using high and low estimated breeding value populations.International journal of biological sciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMorbidity and mortality rates of low birth weight (LBW) newborns at term are higher than rates in normal birth weight (NBW) newborns. LBW newborns are at greater risk to acquire recurrent bacterial and viral infections during their first few weeks of life possibly as an outcome of compromised innate immune functions. As adaptive immunity is in a naive state, increased risk of infection of LBW as compared to NBW newborns may reflect impairments in innate immunity. METHODOLOGY: To characterize the increased susceptibility to infections in LBW newborns we used microarray technology to identify differences in gene expression in LBW newborns (n = 8) compared to NBW newborns (n = 4) using cord blood. The results obtained from the microarray study were validated on a larger number of samples using real time RT-PCR (LBW = 22, NBW = 18) and western blotting (LBW = 12, NBW = 12). The Interferome database was used to identify interferon (IFN) signature genes and ingenuity pathway analysis identified canonical pathways and biological functions associated with the differentially expressed genes in LBW newborns. ELISAs for IFNs and bactericidal/permeability-increasing protein were performed in both LBW and NBW newborns and in adults (LBW = 18, NBW = 18, Adults= 8). PRINCIPAL
findingsUpon microarray analysis, we identified 1,391 differentially expressed genes, of which, 1,065 genes were down-regulated and 326 genes were up-regulated in the LBW compared to NBW newborns. Of note, 70 IFN-signature genes were found to be significantly down-regulated in LBW compared to NBW newborns. Ingenuity pathway analysis revealed pattern recognition receptors signaling including Toll-Like Receptors (TLRs) -1, -5, and -8 genes and IFN signaling as the most significantly impacted pathways. Respiratory infectious diseases were the most significantly affected bio-functions in LBW newborns. CONCLUSION AND SIGNIFICANCE: Diminished PRRs, IFN-signature, and BPI gene expression raises the possibility that impairments in these pathways contribute to the susceptibility of LBW term infants to infection.
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Registered trials
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