ArticlePloS one2013
Increased cytokines response in patients with tuberculosis complicated with chronic obstructive pulmonary disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Difference in systemic inflammation and predictors of acute exacerbation between smoking-associated COPD and tuberculosis-associated COPD.International journal of chronic obstructive pulmonary diseaseTrial
- TAK1 phosphorylation mediates macozinone (PBTZ169) induced innate immune activation against tuberculosis.mSphere · 2025Article
- Analysis of risk factors of unfavorable treatment outcomes in patients with rifampicin-sensitive pulmonary tuberculosis.Medicine · 2025Observational
- Correlation Between Serum Inflammatory Factor Level Changes and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease Complicated by Tuberculosis.International journal of general medicine · 2025Article
- Decreased IL-1 β Secretion as a Potential Predictor of Tuberculosis Recurrence in Individuals Diagnosed with HIV.Biomedicines · 2024Article
- A Novel Inflammatory Indicator for Tuberculosis-Associated Obstructive Pulmonary Disease (TOPD): The Systemic Inflammatory Response Index (SIRI).Journal of inflammation research · 2024Article
- Association of Cytokine Gene Polymorphisms and Their Impact on Active and Latent Tuberculosis in Brazil's Amazon Region.Biomolecules · 2023Article
- High and Low Levels ofInternational journal of molecular sciences · 2023Article
- Tuberculosis-Associated Anemia: A Narrative Review.Cureus · 2022Review
- The ESX-1 Virulence Factors Downregulate miR-147-3p in Mycobacterium marinum-Infected Macrophages.Infection and immunity · 2020Article
- Immunological recovery in patients with pulmonary tuberculosis after intensive phase treatment.The Journal of international medical research · 2018Article
- Emphysema and bronchiectasis in COPD patients with previous pulmonary tuberculosis: computed tomography features and clinical implications.International journal of chronic obstructive pulmonary disease · 2018Article
- Combined approaches using adverse outcome pathways and big data to find potential diseases associated with humidifier disinfectant.Environmental health and toxicology · 2016Article
- Platelet-lymphocyte ratios: a potential marker for pulmonary tuberculosis diagnosis in COPD patients.International journal of chronic obstructive pulmonary disease · 2016Article
- Article
- Identifcation of differentially expressed long non-coding RNAs in CD4+ T cells response to latent tuberculosis infection.The Journal of infection · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the change and its significance of cytokines in patients with pulmonary tuberculosis complicated with COPD.
methodsThe immune function of 152 cases of pulmonary tuberculosis with COPD was detected to compare with 150 cases of patients with pulmonary tuberculosis, 157 cases of patients with COPD and 50 cases of healthy volunteers who were in the hospital during the same period. T lymphocyte cell population in peripheral blood was detected by flow cytometry. The serum levels of sIL-2R, IL-6, IFN-γ, TNF-α were measured using ELISA.
resultsThe percentage of CD4+ T cells in TB patients with or without COPD and COPD patients without TB was significantly lower than that in control group. The percentage of CD4+ T cells in patients with TB and COPD was significantly lower than that in the non-COPD TB patients. The percentage of CD8+ T cells was higher in the TB patients group than that in control group. The CD4+/CD8+ ratio in the TB patients group was significantly lower than that in control group. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in TB patients with or without COPD and COPD patients without TB were significantly higher than those in control group. In addition, sIL-2R, IL-6, TNF-α concentrations in the patients with TB and COPD were higher than those in the non-COPD TB patients. The concentrations of sIL-2R, IL-6, TNF-α, IFN-γ in COPD patients with TB were significantly higher than those in COPD patients without TB. There was a significant negative correlation between serum levels of TNF-α, IL-6 and FEV1 (%, predicted) in COPD without TB group.
conclusionsThe patients with pulmonary tuberculosis complicated with COPD were impaired in cellular immunity, and its extent of immune impairment is more serious than those of the patients with pulmonary tuberculosis and the patients with COPD.
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