ArticlePloS one2013
Myosin-Va-dependent cell-to-cell transfer of RNA from Schwann cells to axons.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- New evidence for secondary axonal degeneration in demyelinating neuropathies.Neuroscience letters · 2021Review
- Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2021Review
- Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.PloS one · 2020Article
- Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia.Journal of molecular neuroscience : MN · 2019Article
- Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes.Cell death & disease · 2016Article
- Schwann cell myelination.Cold Spring Harbor perspectives in biology · 2015Review
- The role of exosomes in peripheral nerve regeneration.Neural regeneration research · 2015Review
- Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.BioMed research international · 2015Review
- Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review).International journal of molecular medicine · 2014Review
- Concepts for regulation of axon integrity by enwrapping glia.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
To better understand the role of protein synthesis in axons, we have identified the source of a portion of axonal RNA. We show that proximal segments of transected sciatic nerves accumulate newly-synthesized RNA in axons. This RNA is synthesized in Schwann cells because the RNA was labeled in the complete absence of neuronal cell bodies both in vitro and in vivo. We also demonstrate that the transfer is prevented by disruption of actin and that it fails to occur in the absence of myosin-Va. Our results demonstrate cell-to-cell transfer of RNA and identify part of the mechanism required for transfer. The induction of cell-to-cell RNA transfer by injury suggests that interventions following injury or degeneration, particularly gene therapy, may be accomplished by applying them to nearby glial cells (or implanted stem cells) at the site of injury to promote regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.