ArticlePloS one2013
Characterization of stratum corneum molecular dynamics by natural-abundance ¹³C solid-state NMR.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 83 citations in OpenAlex.
- Effect of pH on niacinamide skin permeation.Scientific reports · 2026Article
- Molecular dynamics in the stratum corneum of plantar heels in atopic dermatitis patients.Biophysical journal · 2026Article
- Skin penetration enhancers: Mechanistic understanding and their selection for formulation and design.Drug delivery and translational research · 2025Review
- Niacinamide and its impact on stratum corneum hydration and structure.Scientific reports · 2025Article
- Structure and function of skin barrier lipids: Effects of hydration and natural moisturizers in vitro.Biophysical journal · 2024Article
- The Sphingosine and Phytosphingosine Ceramide Ratio in Lipid Models Forming the Short Periodicity Phase: An Experimental and Molecular Simulation Study.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures.Biochimica et biophysica acta. Biomembranes · 2024Article
- The skin barrier: An extraordinary interface with an exceptional lipid organization.Progress in lipid research · 2023Review
- Effect of sphingosine and phytosphingosine ceramide ratio on lipid arrangement and barrier function in skin lipid models.Journal of lipid research · 2023Article
- Molecular Mobility in Keratin-Rich Materials Monitored by Nuclear Magnetic Resonance: A Tool for the Evaluation of Structure-Giving Properties.Biomacromolecules · 2023Article
- Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Catalase Activity in Keratinocytes, Stratum Corneum, and Defatted Algae Biomass as a Potential Skin Care Ingredient.Biomedicines · 2021Article
- Tracing skin aging process: a mini- review of in vitro approaches.Biogerontology · 2021Review
- Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs.Biomedicines · 2021Article
- Skin hydration dynamics investigated by electrical impedance techniques in vivo and in vitro.Scientific reports · 2020Article
- State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models.Skin pharmacology and physiology · 2020Review
- The Effect of UVB Irradiation and Oxidative Stress on the Skin Barrier-A New Method to Evaluate Sun Protection Factor Based on Electrical Impedance Spectroscopy.Sensors (Basel, Switzerland) · 2019Article
- Evidence of hydrocarbon nanodrops in highly ordered stratum corneum model membranes.Journal of lipid research · 2018Article
- Skin hydration: interplay between molecular dynamics, structure and water uptake in the stratum corneum.Scientific reports · 2017Article
- A Possible Percutaneous Penetration Pathway That Should Be Considered.Pharmaceutics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the enormous potential for pharmaceutical applications, there is still a lack of understanding of the molecular details that can contribute to increased permeability of the stratum corneum (SC). To investigate the influence of hydration and heating on the SC, we record the natural-abundance (13)C signal of SC using polarization transfer solid-state NMR methods. Resonance lines from all major SC components are assigned. Comparison of the signal intensities obtained with the INEPT and CP pulse sequences gives information on the molecular dynamics of SC components. The majority of the lipids are rigid at 32°C, and those lipids co-exist with a small pool of mobile lipids. The ratio between mobile and rigid lipids increases with hydration. An abrupt change of keratin filament dynamics occurs at RH = 80-85%, from completely rigid to a structure with rigid backbone and mobile protruding terminals. Heating has a strong effect on the lipid mobility, but only a weak influence on the keratin filaments. The results provide novel molecular insight into how the SC constituents are affected by hydration and heating, and improve the understanding of enhanced SC permeability, which is associated with elevated temperatures and SC hydration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.