ArticlePloS one2013
Comparative genomic analysis of the genus Nocardiopsis provides new insights into its genetic mechanisms of environmental adaptability.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Marine-Derived Rare Actinomycetes: Metabolites and Their Biosynthesis.Marine drugs · 2026Review
- Genome sequencing and comparative analysis of Nocardiopsis moroccensis sp. nov., a halotolerant Actinomycetota from Moroccan hypersaline ecosystem.BMC microbiology · 2026Article
- CED4 and CED4-like Peptides as Effective Plant Parasitic Nematicides.Molecules (Basel, Switzerland) · 2025Article
- GenusMarine drugs · 2022Review
- Biosequestration of carbon dioxide using carbonic anhydrase from novel Streptomyces kunmingensis.Archives of microbiology · 2022Article
- Microbial Degradation of Rubber: Actinobacteria.Polymers · 2021Review
- Genetic and Phenotypic Heterogeneity of the Nocardiopsis alba Strains of Seawater.Current microbiology · 2021Article
- Kinetic, Structural, and Mutational Analysis of Acyl-CoA Carboxylase FromFrontiers in molecular biosciences · 2020Article
- An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes.Metabolites · 2019Article
- The osnR gene of Corynebacterium glutamicum plays a negative regulatory role in oxidative stress responses.Journal of industrial microbiology & biotechnology · 2019Article
- Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species.BMC genomics · 2018Article
- Natural Product Potential of the GenusMarine drugs · 2018Review
- Molecular Characterization of Plasmids Harbored by Actinomycetes Isolated From the Great Salt Plains of Oklahoma Using PFGE and Next Generation Whole Genome Sequencing.Frontiers in microbiology · 2018Article
- Transcriptomic and Ectoine Analysis of HalotolerantFrontiers in microbiology · 2018Article
- Genome-level comparisons provide insight into the phylogeny and metabolic diversity of species within the genus Lactococcus.BMC microbiology · 2017Article
- Comparative genomic analysis of Paenibacillus sp. SSG-1 and its closely related strains reveals the effect of glycometabolism on environmental adaptation.Scientific reports · 2017Article
- Isolation, purification and chemical characterization of a new angucyclinone compound produced by a new halotolerant Nocardiopsis sp. HR-4 strain.World journal of microbiology & biotechnology · 2017Article
- Draft Genome Sequence of Marine-Derived Actinomycete Nocardiopsis sp. Strain TP-A0876, a Producer of Polyketide Pyrones.Genome announcements · 2014Article
- Comparative genomics of the bacterial genus Streptococcus illuminates evolutionary implications of species groups.PloS one · 2014Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Nocardiopsis, a widespread group in phylum Actinobacteria, has received much attention owing to its ecological versatility, pathogenicity, and ability to produce a rich array of bioactive metabolites. Its high environmental adaptability might be attributable to its genome dynamics, which can be estimated through comparative genomic analysis targeting microorganisms with close phylogenetic relationships but different phenotypes. To shed light on speciation, gene content evolution, and environmental adaptation in these unique actinobacteria, we sequenced draft genomes for 16 representative species of the genus and compared them with that of the type species N. dassonvillei subsp. dassonvillei DSM 43111(T). The core genome of 1,993 orthologous and paralogous gene clusters was identified, and the pan-genomic reservoir was found not only to accommodate more than 22,000 genes, but also to be open. The top ten paralogous genes in terms of copy number could be referred to three functional categories: transcription regulators, transporters, and synthases related to bioactive metabolites. Based on phylogenomic reconstruction, we inferred past evolutionary events, such as gene gains and losses, and identified a list of clade-specific genes implicated in environmental adaptation. These results provided insights into the genetic causes of environmental adaptability in this cosmopolitan actinobacterial group and the contributions made by its inherent features, including genome dynamics and the constituents of core and accessory proteins.
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