ArticleFrontiers in integrative neuroscience2013
Serotonin modulation of cortical neurons and networks.
Article in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 1 of them a synthesis that pooled it.
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Who cites it
207 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- HTR1A Polymorphisms and Clinical Efficacy of Antipsychotic Drug Treatment in Schizophrenia: A Meta-Analysis.The international journal of neuropsychopharmacology · 2016Pooled it
- Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.Translational psychiatry · 2026Trial
- A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing.Translational psychiatry · 2025Trial
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Time related effects on functional brain connectivity after serotonergic and cholinergic neuromodulation.Human brain mapping · 2017Trial
- Effects of serotonin 2A/1A receptor stimulation on social exclusion processing.Proceedings of the National Academy of Sciences of the United States of America · 2016Trial
- Thalamic reticular nucleus in the pathophysiology of schizophrenia.Neural regeneration research · 2026Article
- Review
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Serotonin-endocannabinoid crosstalk selectively regulates inhibitory GABAergic inputs in the medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Prenatal stress, excitatory-inhibitory imbalance, and ADHD risk: a hypothesis-driven perspective on psilocybin-induced neuroplasticity.Translational psychiatry · 2026Review
- Assessment of neurotransmitter-related structural brain changes in borderline personality disorder: an MRI study.Scientific reports · 2026Article
- Altered Kynurenine Pathway Metabolism in Drug-naive Children and Adolescents with Generalized Anxiety Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- The Role of Serotonin in Brain Development: From Molecular Pathways to Neurodevelopmental Risk.Cellular and molecular neurobiology · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Multi-Omics Reveals Dysregulated Neurotransmitter Systems in Aging and CNS Disorders.Aging cell · 2026Article
- Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness.bioRxiv : the preprint server for biology · 2026Article
- Cortical functional hierarchy disruption following subcortical stroke.BMC medicine · 2026Article
- Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention.Nature communications · 2026Article
147 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR, respectively) are critically involved in cortical function. Serotonin (5-HT), acting on postsynaptic and presynaptic receptors, is involved in cognition, mood, impulse control and motor functions by (1) modulating the activity of different neuronal types, and (2) varying the release of other neurotransmitters, such as glutamate, GABA, acetylcholine and dopamine. Also, 5-HT seems to play an important role in cortical development. Of all cortical regions, the frontal lobe is the area most enriched in serotonergic axons and 5-HT receptors. 5-HT and selective receptor agonists modulate the excitability of cortical neurons and their discharge rate through the activation of several receptor subtypes, of which the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT3 subtypes play a major role. Little is known, however, on the role of other excitatory receptors moderately expressed in cortical areas, such as 5-HT2C, 5-HT4, 5-HT6, and 5-HT7. In vitro and in vivo studies suggest that 5-HT1A and 5-HT2A receptors are key players and exert opposite effects on the activity of pyramidal neurons in the medial prefrontal cortex (mPFC). The activation of 5-HT1A receptors in mPFC hyperpolarizes pyramidal neurons whereas that of 5-HT2A receptors results in neuronal depolarization, reduction of the afterhyperpolarization and increase of excitatory postsynaptic currents (EPSCs) and of discharge rate. 5-HT can also stimulate excitatory (5-HT2A and 5-HT3) and inhibitory (5-HT1A) receptors in GABA interneurons to modulate synaptic GABA inputs onto pyramidal neurons. Likewise, the pharmacological manipulation of various 5-HT receptors alters oscillatory activity in PFC, suggesting that 5-HT is also involved in the control of cortical network activity. A better understanding of the actions of 5-HT in PFC may help to develop treatments for mood and cognitive disorders associated with an abnormal function of the frontal lobe.
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