ArticleNucleic acids research2013
Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026Article
- Large field of view fluorescence imaging of microfluidic devices with a tandem-lens macroscope.Lab on a chip · 2026Article
- DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation.Cell · 2025Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Dissecting FOXP2 Oligomerization and DNA Binding.Angewandte Chemie (International ed. in English) · 2019Article
- A Phosphomimetic Study Implicates Ser557 in Regulation of FOXP2 DNA Binding.The protein journal · 2018Article
- FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.eLife · 2018Article
- The untold stories of the speech gene, theGenes & cancer · 2018Review
- Article
- DNA-binding properties of FOXP3 transcription factor.Acta biochimica et biophysica Sinica · 2017Article
- Microfluidics for genome-wide studies involving next generation sequencing.Biomicrofluidics · 2017Review
- Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes,Frontiers in molecular neuroscience · 2017Article
- The FOXP2-Driven Network in Developmental Disorders and Neurodegeneration.Frontiers in cellular neuroscience · 2017Article
- The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers.Scientific reports · 2016Article
- Language Impairments in ASD Resulting from a Failed Domestication of the Human Brain.Frontiers in neuroscience · 2016Article
- Insights into the genetic foundations of human communication.Neuropsychology review · 2015Review
- Globularity and language-readiness: generating new predictions by expanding the set of genes of interest.Frontiers in psychology · 2014Article
- The shape of the human language-ready brain.Frontiers in psychology · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The transcription factor forkhead box P2 (FOXP2) is believed to be important in the evolution of human speech. A mutation in its DNA-binding domain causes severe speech impairment. Humans have acquired two coding changes relative to the conserved mammalian sequence. Despite intense interest in FOXP2, it has remained an open question whether the human protein's DNA-binding specificity and chromatin localization are conserved. Previous in vitro and ChIP-chip studies have provided conflicting consensus sequences for the FOXP2-binding site. Using MITOMI 2.0 microfluidic affinity assays, we describe the binding site of FOXP2 and its affinity profile in base-specific detail for all substitutions of the strongest binding site. We find that human and chimp FOXP2 have similar binding sites that are distinct from previously suggested consensus binding sites. Additionally, through analysis of FOXP2 ChIP-seq data from cultured neurons, we find strong overrepresentation of a motif that matches our in vitro results and identifies a set of genes with FOXP2 binding sites. The FOXP2-binding sites tend to be conserved, yet we identified 38 instances of evolutionarily novel sites in humans. Combined, these data present a comprehensive portrait of FOXP2's-binding properties and imply that although its sequence specificity has been conserved, some of its genomic binding sites are newly evolved.
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