ArticleNucleic acids research2013
Transient RNA structure features are evolutionarily conserved and can be computationally predicted.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Sequential structure probing of cotranscriptional RNA folding intermediates.Nature communications · 2025Article
- How does RNA fold dynamically?Journal of molecular biology · 2022Review
- ShapeSorter: a fully probabilistic method for detecting conserved RNA structure features supported by SHAPE evidence.Nucleic acids research · 2022Article
- Thermal adaptation of mRNA secondary structure: stability versus lability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- CoBold: a method for identifying different functional classes of transient RNA structure features that can impact RNA structure formation in vivo.Nucleic acids research · 2021Article
- Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates.Molecular cell · 2021Article
- The International Virus Bioinformatics Meeting 2020.Viruses · 2020Article
- Fixed-parameter tractable sampling for RNA design with multiple target structures.BMC bioinformatics · 2019Article
- Viroid research and its significance for RNA technology and basic biochemistry.Nucleic acids research · 2018Review
- Evaluation of global HIV/SIV envelope gp120 RNA structure and evolution within and among infected hosts.Virus evolution · 2018Article
- Four RNA families with functional transient structures.RNA biology · 2015Article
- e-RNA: a collection of web servers for comparative RNA structure prediction and visualisation.Nucleic acids research · 2014Article
- How to find RNA thermometers.Frontiers in cellular and infection microbiology · 2014Review
- On the importance of cotranscriptional RNA structure formation.RNA (New York, N.Y.) · 2013Review
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Authors and funding
4 authors.
Funding
Abstract
Functional RNA structures tend to be conserved during evolution. This finding is, for example, exploited by comparative methods for RNA secondary structure prediction that currently provide the state-of-art in terms of prediction accuracy. We here provide strong evidence that homologous RNA genes not only fold into similar final RNA structures, but that their folding pathways also share common transient structural features that have been evolutionarily conserved. For this, we compile and investigate a non-redundant data set of 32 sequences with known transient and final RNA secondary structures and devise a dedicated computational analysis pipeline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.