ArticleJournal of bacteriology2013
Identification of new proteins that modulate the germination of spores of bacillus species.
Article in Journal of bacteriology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Structural and functional analysis of themBio · 2026Article
- Recent progress in proteins regulating the germination ofJournal of bacteriology · 2025Review
- Characterization of germinant receptors ofCurrent research in microbial sciences · 2025Article
- Genomic identification of germinant receptors and phenotypic response to germinants inCurrent research in microbial sciences · 2025Article
- Sporulation and Germination in Clostridial Pathogens.Microbiology spectrum · 2019Review
- Structural and functional analyses of the N-terminal domain of the A subunit of aProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Orthologues of Bacillus subtilis Spore Crust Proteins Have a Structural Role in the Bacillus megaterium QM B1551 Spore Exosporium.Applied and environmental microbiology · 2018Article
- Spore Heat Activation Requirements and Germination Responses Correlate with Sequences of Germinant Receptors and with the Presence of a SpecificApplied and environmental microbiology · 2017Article
- Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis.Frontiers in microbiology · 2016Review
- Diversity of the Germination Apparatus inFrontiers in microbiology · 2016Article
- Structure-function analysis of the Bacillus megaterium GerUD spore germinant receptor protein.FEMS microbiology letters · 2015Article
- Bacillus thermoamylovorans Spores with Very-High-Level Heat Resistance Germinate Poorly in Rich Medium despite the Presence of ger Clusters but Efficiently upon Exposure to Calcium-Dipicolinic Acid.Applied and environmental microbiology · 2015Article
- Plasmid-encoded genes influence exosporium assembly and morphology in Bacillus megaterium QM B1551 spores.FEMS microbiology letters · 2015Article
- The effects of heat activation on Bacillus spore germination, with nutrients or under high pressure, with or without various germination proteins.Applied and environmental microbiology · 2015Article
- Article
- Germination of spores of Bacillus species: what we know and do not know.Journal of bacteriology · 2014Review
- Spore germination mediated by Bacillus megaterium QM B1551 SleL and YpeB.Journal of bacteriology · 2014Article
- Levels of germination proteins in Bacillus subtilis dormant, superdormant, and germinating spores.PloS one · 2014Article
- Investigating the functional hierarchy of Bacillus megaterium PV361 spore germinant receptors.Journal of bacteriology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of operons encoding the nutrient germinant receptors (GRs) in dormant spores of Bacillus megaterium and Bacillus subtilis species have small open reading frames (ORFs) of unknown function within or immediately adjacent to the operons. Inactivation of the genes in these ORFs, encoding proteins now termed D proteins, either significantly increased or decreased spore germination via the associated GR but had no effects on germination via non-GR-dependent germinants. These effects on GR-dependent germination were complemented by ectopic expression of the appropriate D gene (gene encoding D protein). However, substitution of noncognate D genes in two GR operons resulted in inhibition of germination via the GR manipulated, although ectopic overexpression of a D gene had no effect on overall GR-dependent germination. The various D genes studied were expressed in the forespore during sporulation in parallel with the associated GR operon, and transcription of a B. subtilis D gene was controlled by RNA polymerase sigma factor σ(G). These results indicate that proteins encoded by small ORFs within or adjacent to operons encoding GRs play major roles in modulating GR function in spores of Bacillus species. In B. subtilis, deletion of a D gene (B. subtilis gerKD [gerKDbs]) adjacent to the gerK operon encoding the GerK GR or ectopic expression or overexpression of gerKDbs had no major effect on the levels of GR subunits or of two other germination proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.