ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2013
Correlation of tumor marker expression with nodal disease burden in metastatic head and neck cancer.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- A pilot study of quantitative real-time polymerase chain reaction metastases detection on sentinel lymph nodes of oral cancer and literature review.Revista da Associacao Medica Brasileira (1992) · 2024Review
- Paradoxical Roles of Desmosomal Components in Head and Neck Cancer.Biomolecules · 2021Review
- Expression and gene regulation network of INHBA in Head and neck squamous cell carcinoma based on data mining.Scientific reports · 2019Article
- Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis.Molecular medicine reports · 2019Article
- Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma.Oncology letters · 2019Article
- Parathyroid Hormone-Like Hormone is a Poor Prognosis Marker of Head and Neck Cancer and Promotes Cell Growth via RUNX2 Regulation.Scientific reports · 2017Article
- Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis.BMC cancer · 2016Article
- Review
- Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo investigate the correlation between the percentage of metastatic tumor present in lymph nodes resected from patients with squamous cell carcinoma of the head and neck (HNSCC) and level of expression of 3 marker genes: pemphigus vulgaris antigen (PVA), parathyroid hormone-related peptide (PTHrP), and tumor-associated calcium signal transducer 1 (TACSTD1). In addition, we investigated whether the level of expression of these 3 markers was associated with clinical outcomes for patients with HNSCC. STUDY
designRetrospective analysis of previously harvested patient samples.
settingThe University of Pittsburgh. SUBJECTS AND
methodsA total of 448 lymph nodes from 92 patients with HNSCC were evaluated for expression of the gene markers PVA, PTHrP, and TACSTD1 using real-time polymerase chain reaction. Confirmation of metastasis was determined by histologic examination. The expression level of these markers versus tumor percentage was analyzed.
resultsAll 3 markers were studied independently and were associated with tumor percentage in metastatic lymph nodes. PVA had the strongest correlation, followed by PTHrP and then TACSTD1. PVA levels had a trend toward association with clinical outcome, specifically time to death caused by cancer, but this was confounded by tumor stage.
conclusionAll 3 tumor gene markers were associated with percentage of tumor cells in metastatic lymph nodes. PVA had the strongest correlation. PVA may add prognostic utility beyond pathologic staging, but this requires analysis of a larger cohort. Prospective studies of tumor volume in metastatic nodes should determine a lower limit threshold of molecular marker detection.
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