Evidence map›Paper›PMID 23625587›Full record

Observational studyObesity (Silver Spring, Md.)2014

Improved memory function two years after bariatric surgery.

Michael L Alosco, Mary Beth Spitznagel, Gladys Strain, Michael Devlin, Ronald Cohen, Robert Paul, Ross D Crosby, James E Mitchell, John Gunstad

2 registry-linked trialsAbstract readObservational Study
In one paragraph

Observational study in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03528044 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors: A Prospective Study of Obese Patients Before and After Bariatric Surgery

TypeinterventionalSponsorKoç UniversityRan2017 to 2022Enrolled50ConditionsObesity, Cognitive DisorderArmsBariatric surgery
NCT05215886 enrolling by invitationnot on this mapstarted 2022, after this paper: background citation

Cognitive Impairment, Obesity, and the Effects of Bariatric Surgery

TypeobservationalSponsorUniversity of California, DavisRan2022 to 2028Enrolled9,500ConditionsObesity, Morbid, Bariatric Surgery CandidateArmsSurgery
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Obesity and episodic memory function.The journal of physiological sciences : JPS · 2018
    Pooled it
  5. Pooled it
  6. Brain effect of bariatric surgery in people with obesity.International journal of obesity (2005) · 2022
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. The relationship between physical activity, sedentary time, and cognitive function following bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Article
  16. Article
  17. Assessment of Obesity-related Metabolic Conditions: a novel objective scoring system better informs metabolic disease severity.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Article
  18. Article
  19. Response to Dr. Buchwald.Obesity surgery · 2024
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michael L AloscoKent State University, Kent, Ohio, USA.
Mary Beth Spitznagel
Gladys Strain
Michael Devlin
Ronald Cohen
Robert Paul
Ross D Crosby
James E Mitchell
John Gunstad

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
WISE II - Obesity and Type-2 Diabetes: Bariatric Surgery Effects on Brain FunctionR01DK099334 · NIDDK · UNIVERSITY OF FLORIDA · PI RONALD A COHEN, Eric Porges · 2014 to 2026
$4.6M
Cognitive Benefits of Cardiac Rehabilitation in Heart FailureR01HL089311 · NHLBI · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2008 to 2012
$2.6M
Cognitive Effects of Bariatric SurgeryR01DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2006 to 2009
$1.5M
Extended Effects of Bariatric Surgery on Cognitive FunctionR56DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2010 to 2010
$296k
NCATS NIH HHS UL1 TR000457NHLBI NIH HHS HL089311NHLBI NIH HHS R01 HL089311NIA NIH HHS P30 AG028740NIDDK NIH HHS DK075119NIDDK NIH HHS R01 DK075119NIDDK NIH HHS R01 DK099334NIDDK NIH HHS R56 DK075119
6 · The paper itself

Abstract

objectiveObesity is as an independent risk factor for poor neurocognitive outcomes, including Alzheimer's disease. Bariatric surgery has recently been shown to result in improved memory at 12-weeks postoperatively. However, the long-term effects of bariatric surgery on cognitive function remain unclear. DESIGN AND

methodsEighty-six individuals (63 bariatric surgery patients, 23 obese controls) were recruited from a prospective study examining the neurocognitive effects of bariatric surgery. All participants completed self-report measurements and a computerized cognitive test battery prior to surgery and at 12-week and 24-month follow-up; obese controls completed measures at equivalent time points.

resultsBariatric surgery patients exhibited high rates of pre-operative cognitive impairments in attention, executive function, memory, and language. Relative to obese controls, repeated measures ANOVA showed improvements in memory from baseline to 12-weeks and 24-months postoperatively (P < 0.05). Regression analyses controlling for baseline factors revealed that a lower BMI at 24-months demonstrated a trend toward significance for improved memory (β = -.30, P = 0.075).

conclusionThese findings suggest that cognitive benefits of bariatric surgery may extend to 24-months postoperatively. Larger prospective studies with extended follow-up periods are needed to elucidate whether bariatric surgery decreases risk for cognitive decline and possibly the development of dementia.

Indexed as

Bariatric SurgeryMemoryAdultBody Mass IndexCognitionCognition DisordersExecutive FunctionFemaleFollow-Up StudiesHumansMaleMiddle AgedObesityPostoperative PeriodProspective StudiesSelf Report

Identifiers

PMID23625587
PMCPMC4054602

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.