Evidence map›Paper›PMID 23625374›Full record

ArticleJournal of dental research2013

Expression and function of enamel-related gene products in calvarial development.

P Atsawasuwan, X Lu, Y Ito, Y Chen, G Gopinathan, C A Evans, A B Kulkarni, C W Gibson, X Luan, T G H Diekwisch

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Biomimetic Aspects of Oral and Dentofacial Regeneration.Biomimetics (Basel, Switzerland) · 2020
    Review
  8. Article
  9. Enamel biomimetics-fiction or future of dentistry.International journal of oral science · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

P AtsawasuwanBrodie Laboratory for Craniofacial Genetics, University of Illinois at Chicago, Chicago, IL 60612, USA.
X Lu
Y Ito
Y Chen
G Gopinathan
C A Evans
A B Kulkarni
C W Gibson
X Luan
T G H Diekwisch
University of Illinois Chicago · USNational Institute of Dental and Craniofacial Research · USUniversity of Pennsylvania · US

Funding

Molecular Roles of Cdk5 in Neuronal Functions and Pain SignalingZIADE000664 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2009 to 2025
$20.4M
Ameloblastin Function in Periodontal DevelopmentR01DE019155 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LUAN, XIANGHONG · 2008 to 2012
$1.9M
Enamel Structure Sophistication throuth Amelogenin EvolutionR01DE018900 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LUAN, XIANGHONG · 2008 to 2011
$1.5M
Ameloblastin Function in the Periodontal LigamentR03DE018057 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LUAN, XIANGHONG · 2007 to 2008
$156k
NIDCR NIH HHS DE18057NIDCR NIH HHS DE18900NIDCR NIH HHS DE19155NIDCR NIH HHS R01 DE018900NIDCR NIH HHS R01 DE019155NIDCR NIH HHS R03 DE018057
6 · The paper itself

Abstract

Enamel-related gene products (ERPs) are detected in non-enamel tissues such as bone. We hypothesized that, if functional, ERP expression corresponds with distinct events during osteoblast differentiation and affects bone development and mineralization. In mouse calvariae and MC3T3 cells, expression profiles of enamel-related gene products (ERPs) correlated with key events in post-natal calvarial development and MC3T3 cell mineralization. Developing skulls from both Amel- and Ambn-deficient animals were approximately 15% shorter when compared with those of wild-type controls, and their sutures remained patent for a longer period of time. Analysis of Amel- and Ambn-deficient calvariae and calvarial osteoblast cultures revealed a dramatic reduction in mineralized nodules, a significant reduction in Runx2, Sp7, Ibsp, and Msx2 expression, and a reduction in Alx4 in Amel-deficient calvariae vs. an increase in Alx4 in Ambn-deficient calvariae. Analysis of these data indicates that ERP expression follows defined developmental profiles and affects osteoblast differentiation, mineralization, and calvarial bone development. We propose that, in parallel to their role in the developing enamel matrix, ERPs have retained an evolutionary conserved function related to the biomineralization of bones.

Indexed as

3T3 CellsAmelogeninAnimalsBone DevelopmentCalcification, PhysiologicCell Culture TechniquesCell DifferentiationCollagen Type ICollagen Type I, alpha 1 ChainConserved SequenceCore Binding Factor Alpha 1 SubunitCranial SuturesDental Enamel ProteinsHomeodomain ProteinsIntegrin-Binding SialoproteinIntracellular Signaling Peptides and ProteinsAlx4 protein, mouseAmbn protein, mouseAmelogeninAmelx protein, mouseAmtn protein, mouseCollagen Type ICollagen Type I, alpha 1 ChainCore Binding Factor Alpha 1 SubunitDental Enamel ProteinsHomeodomain ProteinsIbsp protein, mouseIntegrin-Binding SialoproteinIntracellular Signaling Peptides and Proteinskallikrein 4KallikreinsMatrix Metalloproteinase 20Mmp20 protein, mouseMSX2 proteinODAM protein, mouseProteinsRunx2 protein, mouseSp7 protein, mouseSp7 Transcription FactorTranscription Factorsameloblastinamelogenincalvariaevolutionosteoblastsuture

Identifiers

PMID23625374
PMCPMC3684230
OpenAlexW2049315621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.