ArticleJournal of microbiology (Seoul, Korea)2013
Lactobacillus salivarius strain FDB89 induced longevity in Caenorhabditis elegans by dietary restriction.
Article in Journal of microbiology (Seoul, Korea), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 57 citations in OpenAlex.
- Lactic acid bacteria isolated from mammalian feces exhibit distinct diversity and probiotic traits.World journal of microbiology & biotechnology · 2026Article
- Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation.iMetaOmics · 2024Article
- Geroprotective Effect of Levilactobacillus brevis and Weizmannia coagulans in Caenorhabditis elegans.Probiotics and antimicrobial proteins · 2024Article
- Geroprotective potential of microbiome modulators in the Caenorhabditis elegans model.GeroScience · 2024Review
- Assessment of beneficial effects and identification of host adaptation-associated genes of Ligilactobacillus salivarius isolated from badgers.BMC genomics · 2023Article
- Article
- Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan.Scientific reports · 2022Article
- The effects of polyphenols against oxidative stress inFrontiers in nutrition · 2022Article
- Article
- Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model OrganismIndian journal of microbiology · 2021Review
- The Role of Immune Cells in Oxi-Inflamm-Aging.Cells · 2021Review
- Comparative Genomic Analysis Determines the Functional Genes Related to Bile Salt Resistance inMicroorganisms · 2021Article
- Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease.Molecular medicine reports · 2021Article
- Young at Gut-Turning Back the Clock with the Gut Microbiome.Microorganisms · 2021Review
- Article
- Gerobiotics: probiotics targeting fundamental aging processes.Bioscience of microbiota, food and health · 2021Review
- Comparative Genomic and Functional Evaluations ofFoods (Basel, Switzerland) · 2020Article
- Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities.Gut microbes · 2020Review
- Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we utilized the nematode Caenorhabditis elegans to assess potential life-expanding effect of Lactobacillus salivarius strain FDB89 (FDB89) isolated from feces of centenarians in Bama County (Guangxi, China). This study showed that feeding FDB89 extended the mean life span in C. elegans by up to 11.9% compared to that of control nematodes. The reduced reproductive capacities, pharyngeal pumping rate, growth, and increased superoxide dismutase (SOD) activity and XTT reduction capacity were also observed in FDB89 feeding worms. To probe the anti-aging mechanism further, we incorporated a food gradient feeding assay and assayed the life span of eat-2 mutant. The results demonstrated that the maximal life span of C. elegans fed on FDB89 was achieved at the concentration of 1.0 mg bacterial cells/plate, which was 10-fold greater than that of C. elegans fed on E. coli OP50 (0.1 mg bacterial cells/plate). However, feeding FDB89 could not further extend the life span of eat-2 mutant. These results indicated that FDB89 modulated the longevity of C. elegans in a dietary restriction-dependent manner and expanded the understanding of anti-aging effect of probiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.