ArticleBrain structure & function2014
Striatal patch compartment lesions alter methamphetamine-induced behavior and immediate early gene expression in the striatum, substantia nigra and frontal cortex.
Article in Brain structure & function, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Striosome-Like Structural Connectivity Is Reduced in the Rostral Putamen in Anxiety Disorder.Depression and anxiety · 2026Article
- Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release.Scientific reports · 2021Article
- Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability.PloS one · 2020Article
- Lesions of the Patch Compartment of Dorsolateral Striatum Disrupt Stimulus-Response Learning.Neuroscience · 2019Article
- The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra.PloS one · 2018Article
- Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway.PloS one · 2018Article
- Blockade of patch-based μ opioid receptors in the striatum attenuates methamphetamine-induced conditioned place preference and reduces activation of the patch compartment.European journal of pharmacology · 2017Article
- Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism.Frontiers in neuroanatomy · 2017Article
- Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration.Brain research · 2015Article
- Severe drug-induced repetitive behaviors and striatal overexpression of VAChT in ChAT-ChR2-EYFP BAC transgenic mice.Frontiers in neural circuits · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Methamphetamine (METH) induces stereotypy, which is characterized as inflexible, repetitive behavior. Enhanced activation of the patch compartment of the striatum has been correlated with stereotypy, suggesting that stereotypy may be related to preferential activation of this region. However, the specific contribution of the patch compartment to METH-induced stereotypy is not clear. To elucidate the involvement of the patch compartment to the development of METH-induced stereotypy, we determined if destruction of this sub-region altered METH-induced behaviors. Animals were bilaterally infused in the striatum with the neurotoxin dermorphin-saporin (DERM-SAP; 17 ng/μl) to specifically ablate the neurons of the patch compartment. Eight days later, animals were treated with METH (7.5 mg/kg), placed in activity chambers, observed for 2 h and killed. DERM-SAP pretreatment significantly reduced the number and total area of mu-labeled patches in the striatum. DERM-SAP pretreatment significantly reduced the intensity of METH-induced stereotypy and the spatial immobility typically observed with METH-induced stereotypy. In support of this observation, DERM-SAP pretreatment also significantly increased locomotor activity in METH-treated animals. In the striatum, DERM-SAP pretreatment attenuated METH-induced c-Fos expression in the patch compartment, while enhancing METH-induced c-Fos expression in the matrix compartment. DERM-SAP pretreatment followed by METH administration augmented c-Fos expression in the SNpc and reduced METH-induced c-Fos expression in the SNpr. In the medial prefrontal, but not sensorimotor cortex, c-Fos and zif/268 expression was increased following METH treatment in animals pre-treated with DERM-SAP. These data indicate that the patch compartment is necessary for the expression of repetitive behaviors and suggests that alterations in activity in the basal ganglia may contribute to this phenomenon.
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