ArticleEnvironmental science and pollution research international2013
Blood nickel and chromium levels in association with smoking and occupational exposure among head and neck cancer patients in Tunisia.
Article in Environmental science and pollution research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- The waterpipe smoking and human health: a systematic review and meta-analysis of 191 observational studies.Systematic reviews · 2025Pooled it
- The preventive and carcinogenic effect of metals on cancer: a systematic review.BMC public health · 2024Pooled it
- Cancer risk in waterpipe smokers: a meta-analysis.International journal of public health · 2017Pooled it
- Modifiable risk factors for cancer in the middle East and North Africa: a scoping review.BMC public health · 2024Article
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review.Frontiers in public health · 2024Review
- Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study.Journal of exposure science & environmental epidemiology · 2023Article
- Chromium and lead levels and alteration in DDPH inhibition in patients with breast cancer undergoing chemotherapy.Caspian journal of internal medicine · 2023Article
- Biochemical and reproductive biomarker analysis to study the consequences of heavy metal burden on health profile of male brick kiln workers.Scientific reports · 2022Article
- Assessing reference levels of nickel and chromium in cord blood, maternal blood and placenta specimens from Ankara, TurkeyJournal of the Turkish German Gynecological Association · 2021Article
- Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival.Scientific reports · 2020Article
- Mortality from Selected Cancers among Brazilian Mechanics.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- MOFs-carbon hybrid nanocomposites in environmental protection applications.Environmental science and pollution research international · 2020Review
- Household Smoking Status and Heavy Metal Concentrations in Toenails of Children.International journal of environmental research and public health · 2019Observational
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
- Tobacco influence in heavy metals levels in head and neck cancer cases.Environmental science and pollution research international · 2018Article
- Risk assessment of occupational exposure to heavy metal mixtures: a study protocol.BMC public health · 2018Article
- Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system.Inhalation toxicology · 2017Review
- Genotoxic effects of cadmium in human head and neck cell line SQ20B.Environmental science and pollution research international · 2016Article
- Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China.Environmental science and pollution research international · 2015Article
- Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease.Environmental science and pollution research international · 2015Article
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7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic exposure to chromium (Cr) and nickel (Ni) has long been recognized as being capable to increase head and neck cancer (HNC) incidence among exposed human populations. This study represents the first biomonitoring of Cr and Ni exposure in Tunisia and focuses on a possible association with HNC risk. The aim of the present study was to evaluate the concentrations of Cr and Ni in the blood of HNC patients and controls. Metals blood levels of 169 HNC patients and 351 controls were determined using a Perkin-Elmer Analyst 800 Atomic Absorption Spectrometer. Mean blood levels of Cr and Ni in HNC cases (52.15 and 111.60 μg/L, respectively) were significantly higher than those of controls (37.04 and 30.50 μg/L, respectively). Cases' blood levels of Cr and Ni were significantly higher than those of controls after controlling for the other risk factors of HNC, including smoking, shisha consumption, occupational exposure, and nearby environment (P<0.05). Among these risk factors, smoking and occupational exposure presented the most significant association with HNC (odds ratio (OR)=6.54 and 7.66, respectively, P<0.001). Cr and Ni levels in blood sample of cases and controls that are smoker/occupationally exposed were higher than that of non-smoker/non-occupationally exposed (P<0.05). Smokers who are occupationally exposed present the most significant association with HNC (OR=25.08, P<0.0001). High levels of blood Cr (OR=2.09) and high levels of blood Ni (OR=8.87) were strongly associated with HNC after other potential confounders were controlled (P=0.004 and P<0.0001, respectively). This study suggested a potential role of Cr and Ni in the mechanism of HNC development.
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