Evidence map›Paper›PMID 23625025›Full record

SynthesisIntegrative cancer therapies2013

Adverse events associated with complementary and alternative medicine use in ovarian cancer patients.

Erin S Sweet, Leanna J Standish, Barbara A Goff, M Robyn Andersen

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Integrative cancer therapies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Erin S SweetBastyr University, Kenmore, WA, USA.
Leanna J Standish
Barbara A Goff
M Robyn Andersen
University of Washington · USBastyr University · USFred Hutch Cancer Center · US

Funding

Training in Complementary and Alternative Medical ResearchT32AT000815 · NCCIH · BASTYR UNIVERSITY · PI STANDISH, LEANNA J · 2002 to 2011
$3.2M
NCCIH NIH HHS 2 T32 AT000815NCCIH NIH HHS T32 AT000815
6 · The paper itself

Abstract

introductionMany women with ovarian cancer are choosing to include complementary and alternative medicine (CAM) substances in conjunction with their conventional treatment for ovarian cancer. Many oncologists express concern that the adjunct use of CAM substances may be detrimental to the achievement of therapeutic levels of chemotherapy leading to increases in drug toxicity, under-treatment of disease or other adverse events. In an effort to ascertain the extent of the potential problem with simultaneous use of CAM with conventional treatment we undertook comprehensive systematic review of published case reports describing CAM-related adverse events among ovarian cancer patients. STUDY

designThis article describes a systematic literature review.

methodsThe Natural Medicines Comprehensive Database (NMCD). PubMed, EMBASE® and the Cochrane Central Register of Controlled Trials (CCTR) were systematically reviewed for research articles pertaining to case reports describing adverse events in patients, and clinical trials which examined the effects of herbs and supplements used during cancer treatment.

resultsOnly one case report and one clinical trial were identified which met our inclusion criteria and were relevant to the current investigation.

conclusionAlthough there are concerns about the potential for adverse events related to concurrent use of CAM substances during conventional treatment we found few case reports and clinical trials in the literature which support this.

Indexed as

Antineoplastic AgentsComplementary TherapiesDietary SupplementsFemaleHumansOvarian NeoplasmsPhytotherapyPlant ExtractsAntineoplastic AgentsPlant ExtractsCAM–drug interactionschemotherapycomplementary and alternative medicineherbsintegrative oncologyoncologyovarian cancersupplements

Identifiers

PMID23625025
PMCPMC4613776
OpenAlexW2150027673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.