ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
A prospective study of characteristics and outcomes of bacteremia in patients with solid organ or hematologic malignancies.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Clinical and microbiological characteristics of polymicrobial bloodstream infections in hematologic malignancy patients: a cross-sectional study.BMC infectious diseases · 2026Article
- Beyond bacteremia: clinical phenotypes and determinants of mortality in hospitalized adults with community-acquired urinary tract infection.Frontiers in medicine · 2026Article
- Pathogenic spectrum and drug resistance of bloodstream infection in patients with acute myeloid leukaemia: a single centre retrospective study.Frontiers in cellular and infection microbiology · 2024Article
- Clinical and Epidemiological Characteristics of Bloodstream Infections in Head and Neck Cancer Patients: A Decadal Observational Study.Journal of clinical medicine · 2022Article
- Clinical factors predictive of Gram-negative bloodstream infection at the Emergency Department.Germs · 2022Article
- Clinical Analysis of Bloodstream Infection ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- An eleven-year cohort of bloodstream infections in 552 febrile neutropenic patients: resistance profiles of Gram-negative bacteria as a predictor of mortality.Annals of hematology · 2020Article
- Is current initial empirical antibiotherapy appropriate to treat bloodstream infections in short-duration chemo-induced febrile neutropenia?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Observational
- Shock and Early Death in Hematologic Patients with Febrile Neutropenia.Antimicrobial agents and chemotherapy · 2019Review
- The incidence, risk factors and outcomes of early bloodstream infection in patients with malignant hematologic disease after unrelated cord blood transplantation: a retrospective study.BMC infectious diseases · 2018Article
- Comparison of mono- and combination antibiotic therapy for the treatment ofExperimental and therapeutic medicine · 2018Article
- Prospective Evaluation of Infection Episodes in Cancer Patients in a Tertiary Care Academic Center: Microbiological Features and Risk Factors for Mortality.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2016Article
- Prevalence and risk factors of Gram-negative bacilli causing blood stream infection in patients with malignancy.Saudi medical journal · 2016Article
- [Pathogens and clinical characteristics of bacterial infection in hematology department between 2010 and 2014].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2016Article
- Review
- Bloodstream infections in patients with solid tumors.Virulence · 2016Review
- Infection with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae in cancer patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Prevention of transmission of multidrug-resistant organisms during catheter exchange using antimicrobial catheters.Antimicrobial agents and chemotherapy · 2014Article
- Characteristics, risk factors and outcomes of adult cancer patients with extensively drug-resistant Pseudomonas aeruginosa infections.Infection · 2014Article
- Risk factors for mortality in patients with Pseudomonas aeruginosa bacteremia; retrospective study of impact of combination antimicrobial therapy.BMC infectious diseases · 2014Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the epidemiology and outcomes of bacteremia in patients with hematologic or solid organ malignancies cared for at the University Hospital of Heraklion, Greece.
methodsThis prospective study was conducted during a 4-year period (2007-2011). Patients with bacterial and fungal blood stream infections were followed until discharge. Mortality was the primary outcome, while duration of hospitalization, relapses, time to relapse, and defervescence were the secondary outcomes.
resultsNinety-nine patients with neoplasia (104 episodes) were included. Bacteremia developed mainly in patients with hematologic malignancies (56%). Secondary bacteremias due to respiratory and urinary tract infections were most commonly identified. Gram-negative bacteria were the predominantly isolated pathogens (65%); Pseudomonas spp. was the most common cause (19%), followed closely by E. coli (18%) and Klebsiella pneumoniae (17%). In-hospital mortality was 26.2%. No differences in mortality were seen among patients in different subgroups according to isolated bacteria (according to Gram's stain, species, or number of isolated bacteria in positive cultures), hematologic or solid organ malignancy, neutropenia, and primary or secondary bacteremia. However, patients with bacteremia due to extensively drug resistant bacteria had higher mortality than patients with bacteremia due to multidrug resistant or susceptible pathogens. Patients required a prolonged period of hospitalization (21.8 ± 14.9 days), which was complicated with relapses or reinfections in another body site in 27 % of them.
conclusionGram-negative bacteria were the predominantly isolated pathogens from patients with cancer in our population. The overall mortality remains high.
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