ArticleMolecular imaging and biology2013
Direct, quantitative, and noninvasive imaging of the transport of active agents through intact brain with positron emission tomography.
Article in Molecular imaging and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Focal, remote-controlled, chronic chemical modulation of brain microstructures.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor.NMR in biomedicine · 2015Article
- Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography.Bioconjugate chemistry · 2014Article
- Single compartment drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeOur goal was to use positron emission tomography (PET) to analyze the movement of radiolabeled agents in tissue to enable direct measurement of drug delivery to the brain. PROCEDURES: Various (11)C- and (18) F-labeled compounds were delivered directly to an agarose phantom or rat striatum. Concentration profiles were extracted for analysis and fitted to diffusion models.
resultsDiffusion coefficients ranged from 0.075 ± 0.0026 mm(2)/min ([(18) F]fluoride ion, 18 Da) to 0.0016 ± 0.0018 mm(2)/min ([(18) F]NPB4-avidin, 68 kDa) and matched well with predictions based on molecular weight (R (2) = 0.965). The tortuosity of the brain extracellular space was estimated to be 1.56, with the tissue clearance halftime of each tracer in the brain varying from 19 to 41 min.
conclusionsPET is an effective modality to directly quantify the movement of locally delivered drugs or drug carriers. This continuous, noninvasive assessment of delivery will aid the design of better drug delivery methods.
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