ReviewJournal of mammary gland biology and neoplasia2013
Stem cells and the developing mammary gland.
Review in Journal of mammary gland biology and neoplasia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Chemerin Stimulates the Secretory Activity of BME-UV1 Bovine Mammary Epithelial Cells.International journal of molecular sciences · 2024Article
- Characterization of Hyaluronan Localization in the Developing Mammary Gland and Mammary Tumors.Journal of mammary gland biology and neoplasia · 2023Article
- De novo and cell line models of human mammary cell transformation reveal an essential role for Yb-1 in multiple stages of human breast cancer.Cell death and differentiation · 2022Article
- Macrophages and Stem Cells-Two to Tango for Tissue Repair?Biomolecules · 2021Review
- Distinct Shades of Adipocytes Control the Metabolic Roles of Adipose Tissues: From Their Origins to Their Relevance for Medical Applications.Biomedicines · 2021Review
- Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis.Journal of mammary gland biology and neoplasia · 2020Review
- Progesterone and Breast Cancer.Endocrine reviews · 2020Review
- Transcriptional regulation of normal human mammary cell heterogeneity and its perturbation in breast cancer.The EMBO journal · 2019Review
- Clonal Analysis of Mouse Mammary Luminal Epithelial Cell Transplants.Stem cells and development · 2019Article
- Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009.Radiation research · 2018Article
- Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development.Cell reports · 2018Article
- Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche.Science (New York, N.Y.) · 2018Article
- Basal-like Breast Cancers: From Pathology to Biology and Back Again.Stem cell reports · 2018Review
- Amphiregulin regulates proliferation and migration of HER2-positive breast cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2018Article
- Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages.Cell reports · 2017Article
- Lgr5 is a marker for fetal mammary stem cells, but is not essential for stem cell activity or tumorigenesis.NPJ breast cancer · 2017Article
- Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity.NPJ breast cancer · 2017Article
- Can widely used cell type markers predict the suitability of immortalized or primary mammary epithelial cell models?Biological research · 2016Article
- Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.Oncogene · 2015Article
- A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.Breast cancer research : BCR · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The mammary gland undergoes dynamic changes throughout life. In the mouse, these begin with initial morphogenesis of the gland in the mid-gestation embryo followed by hormonally regulated changes during puberty and later in adulthood. The adult mammary gland contains a hierarchy of cell types with varying potentials for self-maintenance and differentiation. These include cells able to produce complete, functional mammary glands in vivo and that contain daughter cells with the same remarkable regenerative potential, as well as cells with more limited clonogenic activity in vitro. Here we review how applying in vitro and in vivo methods for quantifying these cells in adult mammary tissue to fetal mammary cells has enabled the first cells fulfilling the functional criteria of transplantable, isolated mammary stem cells to be identified a few days before birth. Thereafter, the number of these cells increases rapidly. Populations containing these fetal stem cells display growth and gene expression programs that differ from their adult counterparts but share signatures characteristic of certain types of breast cancer. Such observations reinforce growing evidence of important differences between tissue-specific fetal and adult cells with stem cell properties and emphasize the merits of investigating their molecular basis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.