ArticlePsychopharmacology2013
Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- A Dimer for Dinner: The Impact of GHS-R1a Heterodimerization on Feeding Circuits.Biomolecules · 2026Review
- Central administration of C-type natriuretic peptide (CNP) modulates food consumption in broilers: involvement of dopaminergic, melanocortinergic, and neuropeptide Y receptors.Veterinary research communications · 2025Article
- Endogenous Opioids in the Homeostatic Regulation of Hunger, Satiety, and Hedonic Eating: Neurobiological Foundations.Advances in neurobiology · 2024Review
- Brain circuits for promoting homeostatic and non-homeostatic appetites.Experimental & molecular medicine · 2022Review
- Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test.Journal of the Endocrine Society · 2018Article
- The cellular and molecular bases of leptin and ghrelin resistance in obesity.Nature reviews. Endocrinology · 2017Review
- Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.Oncotarget · 2016Article
- Palatability Can Drive Feeding Independent of AgRP Neurons.Cell metabolism · 2015Article
- Ghrelin.Molecular metabolism · 2015Review
- Hyperprolactinemia has no effect on plasma ghrelin levels in patients with prolactinoma.Journal of the Turkish German Gynecological Association · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent evidence suggests that ghrelin, a peptidic hormone stimulating food intake, interacts with the dopamine signaling. This interaction has been demonstrated to modulate several effects of ghrelin, such as locomotor activity, memory, and food intake. Ghrelin increases dopamine levels in the shell of the nucleus accumbens stimulating food intake, while ablation of the ghrelin receptor attenuates the hypophagia caused by the activation of dopamine receptor 2. However, it is not known whether the orexigenic action of ghrelin is due to changes in central dopamine receptors. MATERIALS AND
methodsWe used Sprague-Dawley rats injected with different dopamine receptor agonists, antagonists, and ghrelin.
resultsWe demonstrate that the specific central blockade of dopamine receptor 1, 2, and 3 (D1, D2, and D3, respectively) reduces the orexigenic action of ghrelin. Similarly, specific central stimulation, either singly of dopamine receptor 1 or dopamine receptors 2 and 3 simultaneously, causes a significant decrease in ghrelin-induced food intake. Co-stimulation of all three receptors (D1, D2, and D3) also led to a marked attenuation in ghrelin-induced food intake. Importantly, the reduction in ghrelin-induced feeding was not caused by malaise or any type of behavioral alteration.
conclusionTaken together, these data indicate that dopamine receptors play an important role in acute stimulation of feeding behavior induced by central injection of ghrelin.
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