ArticleNature neuroscience2013
Meigo governs dendrite targeting specificity by modulating ephrin level and N-glycosylation.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish.Life science alliance · 2023Article
- Review
- Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning.EMBO reports · 2022Article
- Interneuron Diversity: Toward a Better Understanding of Interneuron Development In the Olfactory System.Journal of experimental neuroscience · 2019Review
- Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation inGenes & development · 2017Article
- Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation.The Journal of cell biology · 2017Article
- Protein N-glycosylation and N-glycan trimming are required for postembryonic development of the pest beetle Tribolium castaneum.Scientific reports · 2016Article
- Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.PloS one · 2016Article
- A STRIPAK component Strip regulates neuronal morphogenesis by affecting microtubule stability.Scientific reports · 2015Article
- Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The role of protein N-glycosylation in neural transmission.Glycobiology · 2014Review
- Review
- The Drosophila blood-brain barrier: development and function of a glial endothelium.Frontiers in neuroscience · 2014Review
- N-glycosylation in regulation of the nervous system.Advances in neurobiologyArticle
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Authors and funding
7 authors.
Funding
Abstract
Neural circuit assembly requires precise dendrite and axon targeting. We identified an evolutionarily conserved endoplasmic reticulum (ER) protein, Meigo, from a mosaic genetic screen in Drosophila melanogaster. Meigo was cell-autonomously required in olfactory receptor neurons and projection neurons to target their axons and dendrites to the lateral antennal lobe and to refine projection neuron dendrites into individual glomeruli. Loss of Meigo induced an unfolded protein response and reduced the amount of neuronal cell surface proteins, including Ephrin. Ephrin overexpression specifically suppressed the projection neuron dendrite refinement defect present in meigo mutant flies, and ephrin knockdown caused a similar projection neuron dendrite refinement defect. Meigo positively regulated the level of Ephrin N-glycosylation, which was required for its optimal function in vivo. Thus, Meigo, an ER-resident protein, governs neuronal targeting specificity by regulating ER folding capacity and protein N-glycosylation. Furthermore, Ephrin appears to be an important substrate that mediates Meigo's function in refinement of glomerular targeting.
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