ArticleDevelopmental biology2013
Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study.Investigative ophthalmology & visual science · 2026Article
- The development and the genetic diseases of the ciliary body.Cell insight · 2024Review
- Retinitis pigmentosa with iris coloboma due to miR-204 gene variant in a Chinese family.Molecular genetics & genomic medicine · 2024Article
- Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium.Molecules and cells · 2023Article
- Impaired neurogenesis and neural progenitor fate choice in a human stem cell model of SETBP1 disorder.Molecular autism · 2023Article
- Article
- Transplantation of retinal pigment epithelium and photoreceptors generated concomitantly via small molecule-mediated differentiation rescues visual function in rodent models of retinal degeneration.Stem cell research & therapy · 2021Article
- MicroRNA Signatures of the Developing Primate Fovea.Frontiers in cell and developmental biology · 2021Article
- Knockdown ofAging · 2020Article
- The transcription factorDisease models & mechanisms · 2020Article
- Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.Cellular and molecular life sciences : CMLS · 2020Article
- Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus.Antiviral research · 2019Article
- The peripheral eye: A neurogenic area with potential to treat retinal pathologies?Progress in retinal and eye research · 2019Review
- Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.Cell reports · 2018Article
- The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Loss of Axin2 Causes Ocular Defects During Mouse Eye Development.Investigative ophthalmology & visual science · 2016Article
- The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain.Brain structure & function · 2016Article
- WNT/β-Catenin Signaling in Vertebrate Eye Development.Frontiers in cell and developmental biology · 2016Review
- MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.The American journal of pathology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ciliary margin (CM) develops in the peripheral retina and gives rise to the iris and the ciliary body. The Wnt/β-catenin signalling pathway has been implicated in ciliary margin development. Here, we tested the hypothesis that in the developing mouse retina Foxg1 is responsible for suppressing the Wnt/β-catenin pathway and restricting CM development. We showed that there is excess CM tissue in Foxg1(-/-) null embryos and this expansion is more pronounced in the nasal retina where Foxg1 normally shows its highest expression levels. Results on expression of a reporter allele for Wnt/β-catenin signalling and of Lef1, a target of Wnt/β-catenin signalling, displayed significant upregulation of this pathway in Foxg1(-/-) nulls at embryonic days 12.5 and 14.5. Interestingly, this upregulation was observed specifically in the nasal retina, where normally very few Wnt-responsive cells are observed. These results indicate a suppressive role of Foxg1 on this signalling pathway. Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.