ArticleExperimental eye research2013
MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.
Article in Experimental eye research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Choroidal Changes in Cerebral Amyloid Angiopathy Studied by Optical Coherence Tomography Angiography.Translational stroke research · 2026Article
- Altered Retinal Hemodynamics and Mean Circulation Time in Spontaneously Hypertensive Rats.Investigative ophthalmology & visual science · 2020Article
- Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players.International ophthalmology · 2020Article
- Comparison of invasive dynamic blood pressure between superior mesenteric artery and common carotid artery in rats.World journal of emergency medicine · 2020Article
- Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.Frontiers in neuroinformatics · 2019Review
- Risk factors for hypertensive retinopathy in a Chinese population with hypertension: The Beijing Eye study.Experimental and therapeutic medicine · 2019Article
- Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood.Addiction biology · 2018Article
- Non-invasive assessment of cerebral oxygenation: A comparison of retinal and transcranial oximetry.PloS one · 2018Article
- Oral Administration of Cilostazol Increases Ocular Blood Flow in Patients with Diabetic Retinopathy.Korean journal of ophthalmology : KJO · 2017Observational
- Magnetic Resonance Imaging of Cerebral Blood Flow in Animal Stroke Models.Brain circulation · 2016Article
- Application of Arterial Spin Labelling in the Assessment of Ocular Tissues.BioMed research international · 2016Review
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- Parametric transfer function analysis and modeling of blood flow autoregulation in the optic nerve head.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Changes in intraocular pressure during coronary artery bypass graft surgery: an observational study.Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Blood flow (BF) in many tissues is stable during significant fluctuations in systemic arterial blood pressure or perfusion pressure under normal conditions. The regulatory mechanisms responsible for this non-passive BF behavior include both local and neural control mechanisms. This study evaluated cerebral BF (CBF), retinal BF (RBF) and choroidal BF (ChBF) responses to acute blood pressure increases in rats using magnetic resonance imaging (MRI). A transient increase in blood pressure inside the MRI scanner was achieved by mechanically inflating a balloon catheter to occlude the descending aorta near the diaphragm. We verified the rat model of mechanical occlusion and MRI approach by first measuring blood-flow regulatory responses to changing BP in the brain under normoxia and hypercapnia where the phenomenon is well documented. Retinal and choroidal blood-flow responses to transient increased arterial pressure were then investigated. In response to an acute increase in blood pressure, RBF exhibited autoregulatory behavior and ChBF exhibited baroregulation similar to that seen in the cerebral circulation. This approach may prove useful to investigate retinal and choroidal vascular dysregulation in rat models of retinal diseases with suspected vascular etiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.