ArticleDevelopmental cell2013
Distinct Rap1 activity states control the extent of epithelial invagination via α-catenin.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The Rap1 GTPase performs two separable functions during cellularization to enable ventral furrow formation.bioRxiv : the preprint server for biology · 2026Article
- A deficiency screen of the X chromosome for Rap1 GTPase dominant interacting genes in Drosophila border cell migration.G3 (Bethesda, Md.) · 2025Article
- The molecular signature ofiScience · 2024Article
- Rap1 regulates lumen continuity via Afadin in renal epithelia.Developmental biology · 2023Article
- The α-Catenin mechanosensing M region is required for cell adhesion during tissue morphogenesis.The Journal of cell biology · 2023Article
- Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms.Molecular biology of the cell · 2023Article
- An RNAi Screen for Genes Required for Growth ofG3 (Bethesda, Md.) · 2019Article
- Rap1 GTPase promotes coordinated collective cell migration in vivo.Molecular biology of the cell · 2018Article
- Vertex sliding drives intercalation by radial coupling of adhesion and actomyosin networks duringeLife · 2018Article
- Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.Journal of cell science · 2018Article
- Rap1 Negatively Regulates the Hippo Pathway to Polarize Directional Protrusions in Collective Cell Migration.Cell reports · 2018Article
- Rap1 acts via multiple mechanisms to position Canoe and adherens junctions and mediate apical-basal polarity establishment.Development (Cambridge, England) · 2018Article
- Cellular systems for epithelial invagination.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Polarity protein Par3/Bazooka follows myosin-dependent junction repositioning.Developmental biology · 2017Article
- From morphogen to morphogenesis and back.Nature · 2017Review
- E-cadherin roles in animal biology: A perspective on thyroid hormone-influence.Cell communication and signaling : CCS · 2016Review
- Plexins function in epithelial repair in both Drosophila and zebrafish.Nature communications · 2016Article
- Mechanics of tissue compaction.Seminars in cell & developmental biology · 2015Review
- Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics.Development (Cambridge, England) · 2015Article
- The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation.Developmental biology · 2014Article
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3 authors.
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Abstract
Localized cell shape change initiates epithelial folding, while neighboring cell invagination determines the final depth of an epithelial fold. The mechanism that controls the extent of invagination remains unknown. During Drosophila gastrulation, a higher number of cells undergo invagination to form the deep posterior dorsal fold, whereas far fewer cells become incorporated into the initially very similar anterior dorsal fold. We find that a decrease in α-catenin activity causes the anterior fold to invaginate as extensively as the posterior fold. In contrast, constitutive activation of the small GTPase Rap1 restricts invagination of both dorsal folds in an α-catenin-dependent manner. Rap1 activity appears spatially modulated by Rapgap1, whose expression levels are high in the cells that flank the posterior fold but low in the anterior fold. We propose a model whereby distinct activity states of Rap1 modulate α-catenin-dependent coupling between junctions and actin to control the extent of epithelial invagination.
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