ArticleBiological psychiatry2013
Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 91 citations in OpenAlex.
- Prevalence of CMV, EBV, HPV, and HSV among South Asian healthy population: A systematic review and meta-analysis.PLOS global public health · 2026Article
- Placental Alterations in Autism Spectrum Disorder: An In Silico Approach to circRNA-miRNA-mRNA Networks.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta.Endocrinology · 2025Article
- Dysregulated levels of proangiogenic proteins in the placentas of children with autism spectrum disorder and attention-deficit hyperactivity disorder.Frontiers in medicine · 2025Article
- Taprenepag restores maternal-fetal interface homeostasis for the treatment of neurodevelopmental disorders.Journal of neuroinflammation · 2024Article
- Placental Pathology Findings in Unexplained Pregnancy Losses.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- The genetics of autism and steroid-related traits in prenatal and postnatal life.Frontiers in endocrinology · 2023Article
- Trophoblast inclusions and adverse birth outcomes.PloS one · 2022Article
- Association Between Midpregnancy Polyunsaturated Fatty Acid Levels and Offspring Autism Spectrum Disorder in a California Population-Based Case-Control Study.American journal of epidemiology · 2021Article
- The placenta-brain-axis.Journal of neuroscience research · 2021Review
- The Prenatal Hormone Milieu in Autism Spectrum Disorder.Frontiers in psychiatry · 2021Review
- Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes.Placenta · 2021Article
- Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior.Neurobiology of stress · 2020Article
- Placental gross shape differences in a high autism risk cohort and the general population.PloS one · 2018Article
- Impaired Redox Control in Autism Spectrum Disorders: Could It Be the X in GxE?Current psychiatry reports · 2017Review
- The placental interleukin-6 signaling controls fetal brain development and behavior.Brain, behavior, and immunity · 2017Article
- Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Untangling the most probable role for vitamin DDermato-endocrinology · 2017Article
- Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study.Environmental epigenetics · 2016Article
- Structural Development of Human Fetal and Preterm Brain Cortical Plate Based on Population-Averaged Templates.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGestation is a critical window for neurodevelopmental vulnerability. This study examined whether the presence of trophoblast inclusions (TIs) in the placenta could serve as a predictor for children at elevated risk for autism spectrum disorder (ASD).
methodsPlacentas were obtained from 117 births in the MARBLES (Markers of Autism Risk in Babies-Learning Early Signs) cohort of families who have one or more previous biological children with ASD, placing their newborn at elevated risk for neurodevelopmental compromise. Control samples were obtained from 100 uncomplicated term pregnancies of multiparous women with one or more typically developing biological children. Frequency of TIs was compared across the two groups.
resultsPlacentas from at-risk pregnancies had an eightfold increased odds of having two or more TIs compared with control samples (odds ratio: 8.0, 95% confidence interval: 3.6-18.0). The presence of≥2 TIs yielded a sensitivity of 41% and a specificity of 92% for predicting ASD risk status, whereas≥4 TIs yielded a sensitivity of 19%, a specificity of 99.9%, and a positive likelihood ratio of 242 and conservatively predicted an infant with a 74% probability of being at risk for ASD.
conclusionsOur findings suggest that the placentas from women whose fetuses are at elevated risk for autism are markedly different from control placentas. These differences are manifested histologically as TIs. Their identification has the possibility of identifying newborns at risk for ASD who might benefit from targeted early interventions aimed at preventing or ameliorating behavioral symptoms and optimizing developmental outcomes.
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