Trial reportPsychiatry research2013
Negative symptom improvement during cognitive rehabilitation: results from a 2-year trial of Cognitive Enhancement Therapy.
Trial report in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- One-year randomized controlled trial and follow-up of integrated neurocognitive therapy for schizophrenia outpatients.Schizophrenia bulletin · 2015Trial
- Cognitive Remediation as a Tool for Enhancing Treatment Dimensions of Schizophrenic Symptomatology: A Systematic Review of Randomized Controlled Trials.Brain sciences · 2025Review
- Linking social motivation, general motivation, and social cognition to interpersonal functioning in schizophrenia: insights from exploratory graph analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up study.The British journal of psychiatry : the journal of mental science · 2023Article
- Cognitive enhancement interventions are effective for schizophrenia: why not provide them early?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Cognitive dysfunction and disability in people living with schizophrenia.Journal of family medicine and primary care · 2022Article
- The Cognitive Model of Negative Symptoms in Schizophrenia: A Hierarchical Component Model With PLS-SEM.Frontiers in psychiatry · 2021Article
- Cognitive and clinical predictors of community functioning across the psychoses.PsyCh journal · 2020Article
- Early-Stage Negative Symptom Trajectories and Relationships With 13-Year Outcomes in First-Episode Nonaffective Psychosis.Schizophrenia bulletin · 2019Article
- Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophrenia.Molecular neurobiology · 2018Article
- Holistic Management of Schizophrenia Symptoms Using Pharmacological and Non-pharmacological Treatment.Frontiers in public health · 2018Review
- Using Functional Analysis as a Framework to Guide Individualized Treatment for Negative Symptoms.Frontiers in psychology · 2017Review
- Social cognition in patients at ultra-high risk for psychosis: What is the relation to social skills and functioning?Schizophrenia research. Cognition · 2016Article
- Perspectives on the Use of eHealth in the Management of Patients With Schizophrenia.The Journal of nervous and mental disease · 2016Article
- Development of the Positive Emotions Program for Schizophrenia: An Intervention to Improve Pleasure and Motivation in Schizophrenia.Frontiers in psychiatry · 2016Article
- Social cognition, social competence, negative symptoms and social outcomes: Inter-relationships in people with schizophrenia.Journal of psychiatric research · 2015Article
- Article
- Recent advances in understanding schizophrenia.F1000prime reports · 2014Review
- Psychosocial treatments for negative symptoms in schizophrenia: current practices and future directions.Clinical psychology review · 2013Review
- COVID-19 Pandemic and the Importance of Cognitive Rehabilitation.Basic and clinical neuroscienceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cognitive rehabilitation has shown beneficial effects on cognition in patients with schizophrenia, which may also help to improve negative symptoms due to overlapping pathophysiology between these two domains. To better understand the possible relationship between these areas, we conducted an exploratory analysis of the effects of Cognitive Enhancement Therapy (CET) on negative symptoms. Early course schizophrenia outpatients (n=58) were randomized to 2 years of CET or an Enriched Supportive Therapy (EST) control condition. Results revealed significant and medium-sized (d=0.61) differential improvements favoring CET in overall negative symptoms, particularly social withdrawal, affective flattening, and motor retardation. Neurocognitive improvement was associated with reduced negative symptoms in CET, but not EST patients. No relationships were observed between improvements in emotion processing aspects of social cognition, as measured by the Mayer-Salovey-Caruso Emotional Intelligence Test, and negative symptoms. CET represents an effective cognitive rehabilitation intervention for schizophrenia that may also have benefits to negative symptoms. Future studies specifically designed to examine negative symptoms during the course of cognitive rehabilitation are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.