ArticleBMC public health2013
Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study.
Article in BMC public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HIV behavioural interventions targeted towards older adults: a systematic review.BMC public health · 2014Pooled it
- Risk factors for late HIV diagnosis in England, 2015-2023.HIV medicine · 2026Article
- Survival outcomes and influencing factors in Zhengzhou HIV/AIDS patients following antiretroviral therapy initiation (2014-2024): a retrospective cohort analysis.Frontiers in public health · 2026Article
- Determinants of Late HIV Diagnosis and Advanced HIV Disease Among People Living with HIV in Tanzania.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Transmission network and phylogenetic analysis reveal older male-centered transmission of CRF01_AE and CRF07_BC in Guangxi, China.Emerging microbes & infections · 2023Article
- Increasing HIV early diagnosis by implementing an automated screening strategy in emergency departments.HIV medicine · 2022Observational
- Journeys to HIV testing and diagnosis among adults aged 50+ years in England: A qualitative interview study.Journal of health services research & policy · 2021Article
- Declining trend in HIV new infections in Guangxi, China: insights from linking reported HIV/AIDS cases with CD4-at-diagnosis data.BMC public health · 2020Article
- Correlates of Late Presentation to HIV care in a South Indian Cohort.The American journal of tropical medicine and hygiene · 2018Article
- Late presentation to HIV/AIDS care at the Douala general hospital, Cameroon: its associated factors, and consequences.BMC infectious diseases · 2018Article
- A novel strategy to reduce very late HIV diagnosis in high-prevalence areas in South-West England: serious incident audit.Journal of public health (Oxford, England) · 2017Article
- Missed opportunities for earlier diagnosis of HIV in patients who presented with advanced HIV disease: a retrospective cohort study.BMJ open · 2016Observational
- Late presentation to HIV/AIDS care in Brazil among men who self-identify as heterosexual.Revista de saude publica · 2016Article
- Human Immunodeficiency Virus (HIV).Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016Article
- Impact of Age-related Comorbidities on Five-year Overall Mortality among Elderly HIV-Infected Patients in the Late HAART Era--Role of Chronic Renal Disease.The journal of nutrition, health & aging · 2016Article
- Risk Factors for Acute and Early HIV Infection Among Men Who Have Sex With Men (MSM) in San Diego, 2008 to 2014: A Cohort Study.Medicine · 2015Article
- Lack of awareness in both patients and physicians contributes to a high rate of late presentation in a South West German HIV patient cohort.Infection · 2015Article
- Observational
- Article
- Older Adults with HIV/AIDS in Rural China.The open AIDS journal · 2013Article
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5 authors.
Funding
Abstract
backgroundInitiating therapy with a low CD4 cell count is associated with a substantially greater risk of disease progression and death than earlier initiation. We examined factors associated with late presentation of HIV using the new European consensus definition (CD4 cell count <350 cells/mm3) and mortality.
methodsPatients newly diagnosed with HIV infection at a UK clinic were recruited from January 1996 to May 2010. Factors associated with late presentation were assessed using logistic regression. Factors associated with mortality rates were analysed using Poisson regression.
resultsOf the 1536 included in the analysis, 86% were male and 10% were aged 50 years and older. Half the cohort (49%) had a CD4 cell count below 350 cells/mm3 at presentation ("late presentation"). The frequency of late presentation was highest in those aged 50 years or older and remained unchanged over time (64.3% in 1996-1998 and 65.4% in 2008-2010). In contrast, among those aged less than 50 years, the proportion with late presentation decreased over time (57.1% in 1996-1998 and 38.5% in 2008-2010). Other factors associated with late presentation were African ethnicity and being a male heterosexual.The mortality rate was 15.47/1000 person-years (pyrs) (95%-CI: 13.00-18.41). When compared with younger adults, older individuals had a higher mortality, after adjusting for confounders (rate ratio (RR) = 2.87; 95%-CI: 1.88-4.40).
conclusionsOlder adults were more likely to present late and had a higher mortality. Initiatives to expand HIV testing in clinical and community setting should not neglect individuals aged over 50.
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