ArticleBMC genomics2013
The Nocardia cyriacigeorgica GUH-2 genome shows ongoing adaptation of an environmental Actinobacteria to a pathogen's lifestyle.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Advances in the molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2026Review
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- Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.Annals of clinical microbiology and antimicrobials · 2025Article
- Updated Review onClinical microbiology reviews · 2022Review
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- Comparison of Actinobacteria communities from human-impacted and pristine karst caves.MicrobiologyOpen · 2022Article
- Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov.BMC genomics · 2022Article
- Disseminated Nocardia farcinica involves the spinal cord: a case report and review of the literature.BMC infectious diseases · 2021Review
- Insights from the comparative genome analysis of natural rubber degradingBioinformation · 2021Article
- Microbial risk assessment ofComputational and structural biotechnology journal · 2021Article
- Rapid identification ofOxford medical case reports · 2020Article
- Mce1C and Mce1D facilitate N. farcinica invasion of host cells and suppress immune responses by inhibiting innate signaling pathways.Scientific reports · 2020Article
- Pathogenic Nocardia: A diverse genus of emerging pathogens or just poorly recognized?PLoS pathogens · 2020Review
- Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis.Journal of industrial microbiology & biotechnology · 2019Review
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- Virulence test using nematodes to prescreenPeerJ · 2017Article
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Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNocardia cyriacigeorgica is recognized as one of the most prevalent etiological agents of human nocardiosis. Human exposure to these Actinobacteria stems from direct contact with contaminated environmental matrices. The full genome sequence of N. cyriacigeorgica strain GUH-2 was studied to infer major trends in its evolution, including the acquisition of novel genetic elements that could explain its ability to thrive in multiple habitats.
resultsN. cyriacigeorgica strain GUH-2 genome size is 6.19 Mb-long, 82.7% of its CDS have homologs in at least another actinobacterial genome, and 74.5% of these are found in N. farcinica. Among N. cyriacigeorgica specific CDS, some are likely implicated in niche specialization such as those involved in denitrification and RuBisCO production, and are found in regions of genomic plasticity (RGP). Overall, 22 RGP were identified in this genome, representing 11.4% of its content. Some of these RGP encode a recombinase and IS elements which are indicative of genomic instability. CDS playing part in virulence were identified in this genome such as those involved in mammalian cell entry or encoding a superoxide dismutase. CDS encoding non ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) were identified, with some being likely involved in the synthesis of siderophores and toxins. COG analyses showed this genome to have an organization similar to environmental Actinobacteria.
conclusionN. cyriacigeorgica GUH-2 genome shows features suggesting a diversification from an ancestral saprophytic state. GUH-2 ability at acquiring foreign DNA was found significant and to have led to functional changes likely beneficial for its environmental cycle and opportunistic colonization of a human host.
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