ArticleCell2013
Specified neural progenitors sort to form sharp domains after noisy Shh signaling.
Article in Cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 180 citations in OpenAlex.
- Positional information and information flows in dynamic tissues.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors.eLife · 2026Article
- Optimality as a framework for understanding developmental robustness.Trends in cell biology · 2026Review
- Article
- Tissue fluidity mediates a trade-off between the speed and accuracy of multicellular patterning by cell sorting.Biophysical journal · 2025Article
- Tissue Fluidity Mediates a Trade-off Between the Speed and Accuracy of Multicellular Patterning by Cell Sorting.bioRxiv : the preprint server for biology · 2025Article
- Microtubules regulate tissue-level navigation in skin-resident macrophages.Journal of cell science · 2025Article
- Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization.bioRxiv : the preprint server for biology · 2025Article
- Coping with uncertainty: Challenges for robust pattern formation in dynamical tissues.Seminars in cell & developmental biology · 2025Review
- Blender tissue cartography: an intuitive tool for the analysis of dynamic 3D microscopy data.bioRxiv : the preprint server for biology · 2025Article
- Optogenetic control of Nodal signaling patterns.Development (Cambridge, England) · 2025Article
- Far-red fluorescent genetically encoded calcium ion indicators.Nature communications · 2025Article
- A microfluidic platform for anterior-posterior human endoderm patterning via countervailing morphogen gradientsiScience · 2025Article
- Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness.Nature cell biology · 2025Article
- Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord.bioRxiv : the preprint server for biology · 2025Article
- Synthetically programming natural cell-cell communication pathways for tissue engineering.Current opinion in biomedical engineering · 2024Article
- Article
- A nuclear jamming transition in vertebrate organogenesis.Nature materials · 2024Article
- A fibronectin gradient remodels mixed-phase mesoderm.Science advances · 2024Article
- Tradeoff between speed and robustness in primordium initiation mediated by auxin-CUC1 interaction.Nature communications · 2024Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Sharply delineated domains of cell types arise in developing tissues under instruction of inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. The translation of a morphogen gradient into discrete spatial domains relies on precise signal responses at stable cell positions. However, cells in developing tissues undergoing morphogenesis and proliferation often experience complex movements, which may affect their morphogen exposure, specification, and positioning. How is a clear pattern achieved with cells moving around? Using in toto imaging of the zebrafish neural tube, we analyzed specification patterns and movement trajectories of neural progenitors. We found that specified progenitors of different fates are spatially mixed following heterogeneous Sonic Hedgehog signaling responses. Cell sorting then rearranges them into sharply bordered domains. Ectopically induced motor neuron progenitors also robustly sort to correct locations. Our results reveal that cell sorting acts to correct imprecision of spatial patterning by noisy inductive signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.