ReviewProgress in cardiovascular diseases
The 'perfect storm' and acute coronary syndrome onset: do psychosocial factors play a role?
Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study.Journal of the American Heart Association · 2024Trial
- Clinical predictors of depression treatment outcomes in patients with coronary heart disease.Journal of psychosomatic research · 2016Trial
- Implementing depression treatment for cardiac populations in rapidly changing contexts: Design of the hybrid effectiveness-implementation IHEART DEPCARE trial.American heart journal · 2025Article
- Increasing Uptake of Depression Screening and Treatment Guidelines in Cardiac Patients: A Behavioral and Implementation Science Approach to Developing a Theory-Informed, Multilevel Implementation Strategy.Circulation. Cardiovascular quality and outcomes · 2022Review
- Reduced Rate of Hospital Admissions for heart failure and pulmonary hypertension during Covid-19 infection. Monocentric experience.Acta bio-medica : Atenei Parmensis · 2021Article
- Impact of Acute and Chronic Stress on Thrombosis in Healthy Individuals and Cardiovascular Disease Patients.International journal of molecular sciences · 2020Review
- Depressive symptoms do not discriminate: racial and economic influences between time-varying depressive symptoms and mortality among REGARDS participants.Annals of epidemiology · 2020Article
- Significance of psychosocial factors in cardiology: update 2018 : Position paper of the German Cardiac Society.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Review
- Selected psychological comorbidities in coronary heart disease: Challenges and grand opportunities.The American psychologist · 2018Review
- The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthase.American journal of physiology. Heart and circulatory physiology · 2017Article
- Depression and coronary heart disease.Nature reviews. Cardiology · 2017Review
- Effects of Concurrent Depressive Symptoms and Perceived Stress on Cardiovascular Risk in Low- and High-Income Participants: Findings From the Reasons for Geographical and Racial Differences in Stroke (REGARDS) Study.Journal of the American Heart Association · 2016Observational
- Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.Journal of the American Heart Association · 2016Article
- Psychosocial predictors of long-term mortality among women with suspected myocardial ischemia: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation.Journal of behavioral medicine · 2016Article
- The clinics of acute coronary syndrome.Annals of translational medicine · 2016Review
- Perfect storm: concurrent stress and depressive symptoms increase risk of myocardial infarction or death.Circulation. Cardiovascular quality and outcomes · 2015Observational
- Fear of terror and inflammation ignite heart health decline.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Chest pain characteristics and gender in the early diagnosis of acute myocardial infarction.Current cardiology reports · 2015Review
- Psychosocial stress as a risk factor for sepsis: a population-based cohort study.Psychosomatic medicine · 2015Article
- Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion.Journal of the American Heart Association · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The revolution in cardiac care over the past two decades, characterized by emergent revascularization, drug eluting stents, anti-platelet medications, and advanced imaging has had little impact on overall ACS recurrence, or ACS prevention. The "Perfect Storm" refers to a confluence of events and processes, including atherosclerotic plaque, coronary flow dynamics, hemostatic and fibrinolytic function, metabolic and inflammatory conditions, neurohormonal dysregulation, and environmental events that give rise to, and result in an ACS event. In this article we illustrate the limits of the traditional main effect research model, giving a brief description of the current state of knowledge regarding the development of atherosclerotic plaque and the rupturing of these plaques that defines an ACS event. We then apply the Perfect Storm conceptualization to describe a program of research concerning a psychosocial vulnerability factor that contributes to increased risk of recurrent ACS and early mortality, and that has defied our efforts to identify underlying pathophysiology and successfully mount efforts to fully mitigate this risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.