ArticleBMC plant biology2013
Genome-wide identification and functional analyses of calmodulin genes in Solanaceous species.
Article in BMC plant biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 92 citations in OpenAlex.
- Genome-Wide Characterization of Calmodulin-Binding Transcription Activators Genes inInternational journal of molecular sciences · 2026Article
- Genome-wide identification and characterization of CaM and CML gene family in chickpea (Cicer arietinum L.).Scientific reports · 2026Article
- The regulatory mechanisms of CAM/CML gene family in governing mycorrhizal fungi in Cremastra appendiculata (Orchidaceae).BMC plant biology · 2025Article
- Functional evaluation of pathogenesis-related protein-1 (PR1) genes in mung bean (Vigna radiata) response to Pythium myriotylum.BMC genomics · 2025Article
- Genome-Wide Identification and Expression Analysis of theCurrent issues in molecular biology · 2025Article
- A conserved fungal effector disturbs CaNature communications · 2025Article
- Comprehensive in-silico characterization and expression pattern of calmodulin genes under various abiotic and biotic stresses in Indian mustard (Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Comprehensively characterize the soybean CAM/CML gene family, as it provides resistance against both the soybean mosaic virus andFrontiers in plant science · 2025Article
- A regulatory network involving calmodulin controls phytosulfokine peptide processing during drought-induced flower abscission.The Plant cell · 2024Article
- Integrated Assays of Genome-Wide Association Study, Multi-Omics Co-Localization, and Machine Learning Associated Calcium Signaling Genes with Oilseed Rape Resistance toInternational journal of molecular sciences · 2024Article
- Transcriptome analysis of tomato plants following salicylic acid-induced immunity againstPlant biotechnology (Tokyo, Japan) · 2023Article
- Disentangling the resistant mechanism of Fusarium wilt TR4 interactions with different cultivars and its elicitor application.Frontiers in plant science · 2023Article
- Genome-wide identification and expression analysis of calmodulin and calmodulin-like genes in wheat (Plant signaling & behavior · 2022Article
- Impact of Nanomaterials on the Regulation of Gene Expression and Metabolomics of Plants under Salt Stress.Plants (Basel, Switzerland) · 2022Review
- Genome-Wide Identification of Rapid Alkalinization Factor Family inFrontiers in plant science · 2022Article
- Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.Current genomics · 2021Review
- Non-Canonical Interaction between Calmodulin and Calcineurin Contributes to the Differential Regulation of Plant-Derived Calmodulins on Calcineurin.Journal of chemical information and modeling · 2021Article
- Calmodulin7: recent insights into emerging roles in plant development and stress.Plant molecular biology · 2021Review
- Genome-Wide Characterization and Expression Analysis ofFrontiers in genetics · 2021Article
- Physiological Responses of Cucumber Seedlings to Different Supplemental Light Duration of Red and Blue LED.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalmodulin (CaM) is a major calcium sensor in all eukaryotes. It binds calcium and modulates the activity of a wide range of downstream proteins in response to calcium signals. However, little is known about the CaM gene family in Solanaceous species, including the economically important species, tomato (Solanum lycopersicum), and the gene silencing model plant, Nicotiana benthamiana. Moreover, the potential function of CaM in plant disease resistance remains largely unclear.
resultsWe performed genome-wide identification of CaM gene families in Solanaceous species. Employing bioinformatics approaches, multiple full-length CaM genes were identified from tomato, N. benthamiana and potato (S. tuberosum) genomes, with tomato having 6 CaM genes, N. benthamiana having 7 CaM genes, and potato having 4 CaM genes. Sequence comparison analyses showed that three tomato genes, SlCaM3/4/5, two potato genes StCaM2/3, and two sets of N. benthamiana genes, NbCaM1/2/3/4 and NbCaM5/6, encode identical CaM proteins, yet the genes contain different intron/exon organization and are located on different chromosomes. Further sequence comparisons and gene structural and phylogenetic analyses reveal that Solanaceous species gained a new group of CaM genes during evolution. These new CaM genes are unusual in that they contain three introns in contrast to only a single intron typical of known CaM genes in plants. The tomato CaM (SlCaM) genes were found to be expressed in all organs. Prediction of cis-acting elements in 5' upstream sequences and expression analyses demonstrated that SlCaM genes have potential to be highly responsive to a variety of biotic and abiotic stimuli. Additionally, silencing of SlCaM2 and SlCaM6 altered expression of a set of signaling and defense-related genes and resulted in significantly lower resistance to Tobacco rattle virus and the oomycete pathogen, Pythium aphanidermatum.
conclusionsThe CaM gene families in the Solanaceous species tomato, N. benthamiana and potato were identified through a genome-wide analysis. All three plant species harbor a small set of genes that encode identical CaM proteins, which may manifest a strategy of plants to retain redundancy or enhanced quantitative gene function. In addition, Solanaceous species have evolved one new group of CaM genes during evolution. CaM genes play important roles in plant disease resistance to a variety of pathogens.
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