ArticleJournal of cellular and molecular medicine2013
Telocytes in neuromuscular spindles.
Article in Journal of cellular and molecular medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
- Telocytes in skeletal muscle: Emerging players in homeostasis and repair/regeneration.Histology and histopathology · 2026Review
- The ultrastructural characterization and immunophenotypic features of telocytes in the myocardium and aortic bulb of young and adult Tibetan sheep.BMC veterinary research · 2026Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Distribution characteristics and morphological comparison of telocytes in the aortic bulb and myocardium of yak heart.BMC veterinary research · 2025Article
- Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis.Cell and tissue research · 2024Article
- Telocytes in the Normal and Pathological Peripheral Nervous System.International journal of molecular sciences · 2020Review
- Morphological evidence for telocytes as stromal cells supporting satellite cell activation in eccentric contraction-induced skeletal muscle injury.Scientific reports · 2019Article
- Article
- Emerging diverse roles of telocytes.Development (Cambridge, England) · 2019Review
- Telocytes as a Novel Structural Component in the Muscle Layers of the Goat Rumen.Cell transplantation · 2019Article
- The Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma Formation.Cell transplantation · 2019Article
- Recently Discovered Interstitial Cell Population of Telocytes: Distinguishing Facts from Fiction Regarding Their Role in the Pathogenesis of Diverse Diseases Called "Telocytopathies".Medicina (Kaunas, Lithuania) · 2019Review
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Morphological evidence of telocytes in human synovium.Scientific reports · 2018Article
- Immunophenotypic characterization of telocyte-like cells in pterygium.Molecular vision · 2018Article
- The Na, K-ATPase β-Subunit Isoforms Expression in Glioblastoma Multiforme: Moonlighting Roles.International journal of molecular sciences · 2017Article
- Transmission electron microscope evidence of telocytes in canine dura mater.Journal of cellular and molecular medicine · 2016Article
- Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types.Journal of cellular and molecular medicine · 2016Article
- Ultrastructural identification of telocytes in the muscularis of chicken ileum.Experimental and therapeutic medicine · 2015Article
- The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition.Journal of cellular and molecular medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new cell type named telocyte (TC) has recently been identified in various stromal tissues, including skeletal muscle interstitium. The aim of this study was to investigate by means of light (conventional and immunohistochemical procedures) and electron microscopy the presence of TCs in adult human neuromuscular spindles (NMSs) and lay the foundations for future research on their behaviour during human foetal development and in skeletal muscle pathology. A large number of TCs were observed in NMSs and were characterized ultrastructurally by very long, initially thin, moniliform prolongations (telopodes - Tps), in which thin segments (podomeres) alternated with dilations (podoms). TCs formed the innermost and (partially) the outermost layers of the external NMS capsule and the entire NMS internal capsule. In the latter, the Tps were organized in a dense network, which surrounded intrafusal striated muscle cells, nerve fibres and vessels, suggesting a passive and active role in controlling NMS activity, including their participation in cell-to-cell signalling. Immunohistochemically, TCs expressed vimentin, CD34 and occasionally c-kit/CD117. In human foetus (22-23 weeks of gestational age), TCs and perineural cells formed a sheath, serving as an interconnection guide for the intrafusal structures. In pathological conditions, the number of CD34-positive TCs increased in residual NMSs between infiltrative musculoaponeurotic fibromatosis and varied in NMSs surrounded by lymphocytic infiltrate in inflammatory myopathy. We conclude that TCs are numerous in NMSs (where striated muscle cells, nerves and vessels converge), which provide an ideal microanatomic structure for TC study.
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