Observational studyBipolar disorders2013
Seasonal variation of manic and depressive symptoms in bipolar disorder.
Observational study in Bipolar disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Metabolic plasticity: an evolutionary perspective on metabolic and circadian dysregulation in bipolar disorder.Molecular psychiatry · 2025Review
- Investigating seasonal metabolic variations in bipolar disorder: a targeted metabolomics study.BMC psychiatry · 2025Article
- Bipolar II disorder: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Seasonal mood variation in youth and young adults with bipolar spectrum disorder: A longitudinal prospective analysis.Journal of affective disorders · 2025Article
- Insomnia in seasonal affective disorder: considering the use of benzodiazepines with a focus on lormetazepam.Frontiers in psychiatry · 2025Review
- Patterns of Self-Reported Mental Health Symptoms and Treatment among People Booked into a Large Metropolitan County Jail.Administration and policy in mental health · 2024Article
- The Elusive "Switch Process" in Bipolar Disorder and Photoperiodism: A Hypothesis Centering on NADPH Oxidase-Generated Reactive Oxygen Species Within the Bed Nucleus of the Stria Terminalis.Frontiers in psychiatry · 2022Article
- Maximum Temperature and Solar Radiation as Predictors of Bipolar Patient Admission in an Emergency Psychiatric Ward.International journal of environmental research and public health · 2019Article
- Impact of seasons on stroke-related depression, mediated by vitamin D status.BMC psychiatry · 2018Article
- Seasonality of hospital admissions and birth dates among inpatients with eating disorders: a nationwide population-based retrospective study.Eating and weight disorders : EWD · 2018Article
- Mixed state and suicide: Is the effect of mixed state on suicidal behavior more than the sum of its parts?Bipolar disorders · 2018Article
- Seasonal affective disorder and non-seasonal affective disorders: results from the NESDA study.BJPsych open · 2017Article
- Evaluation of Bipolar Disorder in Several Relapses over Time Using Generalized Estimating Equations.Iranian journal of psychiatry · 2017Article
- Seasonal variation in major depressive episode prevalence in Canada.Epidemiology and psychiatric sciences · 2017Article
- Article
- Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment.Chonnam medical journal · 2017Review
- Seasonal variation in affective and other clinical symptoms among high-risk families for bipolar disorders in an Arctic population.International journal of circumpolar health · 2015Article
- Photoperiodic and circadian bifurcation theories of depression and mania.F1000Research · 2015Review
- Seasonal variation of depressive symptoms in unipolar major depressive disorder.Comprehensive psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesAnalyses of seasonal variation of manic and depressive symptoms in bipolar disorder in retrospective studies examining admission data have yielded conflicting results. We examined seasonal variation of mood symptoms in a prospective cohort with long-term follow-up: the Collaborative Depression Study (CDS).
methodsThe CDS included participants from five academic centers with a prospective diagnosis of bipolar I or II disorder. The sample was limited to those who were followed for at least 10 years of annual or semi-annual assessments. Time series analyses and autoregressive integrated moving average (ARIMA) models were used to assess seasonal patterns of manic and depressive symptoms.
resultsA total of 314 individuals were analyzed (bipolar I disorder, n = 202; bipolar II disorder, n = 112), with both disorders exhibiting the lowest frequency of depressive symptoms in summer and the highest around the winter solstice, though the winter peak in symptoms was statistically significant only with bipolar I disorder. Variation of manic symptoms was more pronounced in bipolar II disorder, with a significant peak in hypomanic symptomatology in the months surrounding the fall equinox.
conclusionsSignificant seasonal variation exists in bipolar disorder, with manic/hypomanic symptoms peaking around the fall equinox and depressive symptoms peaking in the months surrounding the winter solstice in bipolar I disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.