ReviewJournal of neuropsychology2013
Impulsivity and apathy in Parkinson's disease.
Review in Journal of neuropsychology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Diagnosis, treatment and management of apathy in Parkinson's disease: a scoping review.BMJ open · 2020Pooled it
- A multi-pronged investigation of option generation using depression, PET and modafinil.Brain : a journal of neurology · 2022Trial
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- The relationship between apathy and impulsivity in large population samples.Scientific reports · 2021Trial
- Trial
- Sensitivity to negative-feedback processing in people with Parkinson's disease and impulsive-compulsive behaviours.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Decision context and neurobehavioural disturbance in Huntington's disease.Cognitive, affective & behavioral neuroscience · 2026Article
- Network localization of functional and structural correlates of apathy in Parkinson's disease.Frontiers in systems neuroscience · 2026Article
- The relationship between neuropsychiatric dimensions and markers of Parkinson's disease risk in the UK Biobank.NPJ Parkinson's disease · 2025Article
- Goal-directedness deficit in Huntington's disease.Cognitive, affective & behavioral neuroscience · 2025Article
- Active information sampling in health and disease.Neuroscience and biobehavioral reviews · 2025Review
- Article
- Decision cost hypersensitivity underlies Huntington's disease apathy.Brain : a journal of neurology · 2025Article
- Sex differences in behavioral measures of anxiety in a recessive gene knockout (Frontiers in behavioral neuroscience · 2025Article
- Subthalamic stimulation causally modulates human voluntary decision-making to stay or go.NPJ Parkinson's disease · 2024Article
- Apathy and Impulsivity Co-Occur in Huntington's Disease.Brain and behavior · 2024Article
- Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) in an Italian Parkinson's disease cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Electromyographic Characteristics of Postactivation Effect in Dopamine-Dependent Spectrum Models Observed in Parkinson's Disease and Schizophrenia.Biomedicines · 2024Article
- Impaired value-based decision-making in Parkinson's disease apathy.Brain : a journal of neurology · 2024Article
- A Cognitive-Behavioral Model of Apathy in Parkinson's Disease.Parkinson's disease · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Impulse control disorders (ICDs) and apathy are recognized as two important neuropsychiatric syndromes associated with Parkinson's disease (PD), but as yet we understand very little about the cognitive mechanisms underlying them. Here, we review emerging findings, from both human and animal studies, that suggest that impulsivity and apathy are opposite extremes of a dopamine-dependent spectrum of motivated decision making. We first argue that there is strong support for a hypodopaminergic state in PD patients with apathy, as well as for an association between dopamine therapy and development of ICDs. However, there is little evidence for a clear dose-response relationship, and great heterogeneity of findings. We argue that dopaminergic state on its own is an insufficient explanation, and suggest instead that there is now substantial evidence that both apathy and impulsivity are in fact multi-dimensional syndromes, with separate, dissociable mechanisms underlying their 'surface' manifestations. Some of these mechanisms might be dopamine-dependent. According to this view, individuals diagnosed as impulsive or apathetic may have very different mechanisms underlying their clinical states. We propose that impulsivity and apathy can arise from dissociable deficits in option generation, option selection, action initiation or inhibition and learning. Review of the behavioural and neurobiological evidence leads us to a new conceptual framework that might help understand the variety of functional deficits seen in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.