Evidence map›Paper›PMID 23620729›Full record

Trial reportPloS one2013

Should we still focus that much on cardiovascular mortality in end stage renal disease patients? The CONvective TRAnsport STudy.

Claire H den Hoedt, Michiel L Bots, Muriel P C Grooteman, Albert H A Mazairac, E Lars Penne, Neelke C van der Weerd, Piet M Ter Wee, Menso J Nubé, Renée Levesque, Peter J Blankestijn and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Advance care planning for haemodialysis patients.The Cochrane database of systematic reviews · 2016
    Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Predialysis coronary revascularization and postdialysis mortality.The Journal of thoracic and cardiovascular surgery · 2019
    Observational
  7. Clinical evidence on haemodiafiltration.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Claire H den HoedtDepartment of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
Michiel L Bots
Muriel P C Grooteman
Albert H A Mazairac
E Lars Penne
Neelke C van der Weerd
Piet M Ter Wee
Menso J Nubé
Renée Levesque
Peter J Blankestijn
Marinus A van den Dorpel
CONTRAST investigators
Amsterdam UMC Location VUmc · NLUniversity Medical Center Utrecht · NLCentre Hospitalier de l’Université de Montréal · CAMaasstad Ziekenhuis · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe studied the distribution of causes of death in the CONTRAST cohort and compared the proportion of cardiovascular deaths with other populations to answer the question whether cardiovascular mortality is still the principal cause of death in end stage renal disease. In addition, we compared patients who died from the three most common death causes. Finally, we aimed to study factors related to dialysis withdrawal.

methodsWe used data from CONTRAST, a randomized controlled trial in 714 chronic hemodialysis patients comparing the effects of online hemodiafiltration versus low-flux hemodialysis. Causes of death were adjudicated. The distribution of causes of death was compared to that of the Dutch dialysis registry and of the Dutch general population.

resultsIn CONTRAST, 231 patients died on treatment. 32% died from cardiovascular disease, 22% due to infection and 23% because of dialysis withdrawal. These proportions were similar to those in the Dutch dialysis registry and the proportional cardiovascular mortality was similar to that of the Dutch general population. cardiovascular death was more common in patients <60 years. Patients who withdrew were older, had more co-morbidity and a lower mental quality of life at baseline. Patients who withdrew had much co-morbidity. 46% died within 5 days after the last dialysis session.

conclusionsAlthough the absolute risk of death is much higher, the proportion of cardiovascular deaths in a prevalent end stage renal disease population is similar to that of the general population. In older hemodialysis patients cardiovascular and non-cardiovascular death risk are equally important. Particularly the registration of dialysis withdrawal deserves attention. These findings may be partly limited to the Dutch population.

Indexed as

AgedAge DistributionCardiovascular DiseasesCause of DeathFemaleFollow-Up StudiesHumansKidney Failure, ChronicMaleMiddle AgedNetherlandsRegistriesRenal Dialysis

Identifiers

PMID23620729
PMCPMC3631204
OpenAlexW2142617726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.