ArticlePloS one2013
miR-204 targeting of Ankrd13A controls both mesenchymal neural crest and lens cell migration.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- miR-133a-3p and miR-338-3p shape neural crest derivatives in zebrafish.Life science alliance · 2026Article
- "Beyond transcription: How post-transcriptional mechanisms drive neural crest EMT".Genesis (New York, N.Y. : 2000) · 2024Review
- Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.International journal of molecular sciences · 2022Article
- MicroRNAs in neural crest development and neurocristopathies.Biochemical Society transactions · 2022Review
- In Vitro and In Vivo Toxicity Evaluation of Natural Products with Potential Applications as Biopesticides.Toxins · 2021Article
- The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.The EMBO journal · 2021Article
- Exposure to environmental bisphenol A inhibits HTR-8/SVneo cell migration and invasion.Journal of biomedical research · 2020Article
- Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood.Oncotarget · 2020Article
- TRPM3_miR-204: a complex locus for eye development and disease.Human genomics · 2020Review
- Counterregulation of cAMP-directed kinase activities controls ciliogenesis.Nature communications · 2018Article
- MiR-211 is essential for adult cone photoreceptor maintenance and visual function.Scientific reports · 2017Article
- Ecdysone Receptor-based Singular Gene Switches for Regulated Transgene Expression in Cells and Adult Rodent Tissues.Molecular therapy. Nucleic acids · 2016Article
- High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs.Nucleic acids research · 2016Article
- Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression.Molecular cancer therapeutics · 2015Article
- MiR-204 is responsible for inherited retinal dystrophy associated with ocular coloboma.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- TGF-β Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth.PloS one · 2015Article
- Bioactive Functions of Milk Proteins: a Comparative Genomics Approach.Journal of mammary gland biology and neoplasia · 2014Review
- The cellular and molecular mechanisms of vertebrate lens development.Development (Cambridge, England) · 2014Review
- Differential temporal expression of milk miRNA during the lactation cycle of the marsupial tammar wallaby (Macropus eugenii).BMC genomics · 2014Article
- The combination of transcriptomics and informatics identifies pathways targeted by miR-204 during neurogenesis and axon guidance.Nucleic acids research · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of cell adhesion and enhancement of cell motility contribute to epithelial-to-mesenchymal transition during development. These processes are related to a) rearrangement of cell-cell and cell-substrate adhesion molecules; b) cross talk between extra-cellular matrix and internal cytoskeleton through focal adhesion molecules. Focal adhesions are stringently regulated transient structures implicated in cell adhesion, spreading and motility during tissue development. Importantly, despite the extensive elucidation of the molecular composition of focal adhesions, the complex regulation of their dynamics is largely unclear. Here, we demonstrate, using live-imaging in medaka, that the microRNA miR-204 promotes both mesenchymal neural crest and lens cell migration and elongation. Overexpression of miR-204 results in upregulated cell motility, while morpholino-mediated ablation of miR-204 activity causes abnormal lens morphogenesis and neural crest cell mislocalization. Using a variety of in vivo and in vitro approaches, we demonstrate that these actions are mediated by the direct targeting of the Ankrd13A gene, which in turn controls focal cell adhesion formation and distribution. Significantly, in vivo restoration of abnormally elevated levels of Ankrd13A resulting from miR-204 inactivation rescued the aberrant lens phenotype in medaka fish. These data uncover, for the first time in vivo, the role of a microRNA in developmental control of mesenchymal cell migration and highlight miR-204 as a "master regulator" of the molecular networks that regulate lens morphogenesis in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.