Evidence map›Paper›PMID 23620685›Full record

ArticleNature and science of sleep2012

Shift work: health, performance and safety problems, traditional countermeasures, and innovative management strategies to reduce circadian misalignment.

Mark R Smith, Charmane I Eastman

Abstract read
In one paragraph

Article in Nature and science of sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Systematic review of drugs that modify the circadian system's phase-shifting responses to light exposure.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
  3. Guideline
  4. Trial
  5. Trial
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  8. Light therapy in medicine: where do we stand?Annals of translational medicine · 2026
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark R SmithBiological Rhythms Research Laboratory, Rush University Medical Center, Chicago, IL, USA.
Charmane I Eastman

Funding

REDUCING JET-LAG WITH PRACTICAL CIRCADIAN TREATMENTSR01NR007677 · NINR · RUSH UNIVERSITY MEDICAL CENTER · PI EASTMAN, CHARMANE I · 2000 to 2016
$5.7M
Phase response curves for home remedies to treat circadian misalignmentR01HL086934 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI EASTMAN, CHARMANE I · 2007 to 2010
$1.6M
PRACTICAL CIRCADIAN INTERVENTIONS FOR NIGHT SHIFT WORKR01OH003954 · OH · RUSH UNIVERSITY MEDICAL CENTER · PI EASTMAN, CHARMANE I · 1999 to 2007
$722k
MELATONIN, HUMAN CIRCADIAN RHYTHMS, AND SLEEPR01NS035695 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI EASTMAN, CHARMANE I · 1997 to 2000
$232k
NHLBI NIH HHS R01 HL086934NINDS NIH HHS R01 NS035695NINR NIH HHS R01 NR007677NIOSH CDC HHS R01 OH003954
6 · The paper itself

Abstract

There are three mechanisms that may contribute to the health, performance, and safety problems associated with night-shift work: (1) circadian misalignment between the internal circadian clock and activities such as work, sleep, and eating, (2) chronic, partial sleep deprivation, and (3) melatonin suppression by light at night. The typical countermeasures, such as caffeine, naps, and melatonin (for its sleep-promoting effect), along with education about sleep and circadian rhythms, are the components of most fatigue risk-management plans. We contend that these, while better than nothing, are not enough because they do not address the underlying cause of the problems, which is circadian misalignment. We explain how to reset (phase-shift) the circadian clock to partially align with the night-work, day-sleep schedule, and thus reduce circadian misalignment while preserving sleep and functioning on days off. This involves controlling light and dark using outdoor light exposure, sunglasses, sleep in the dark, and a little bright light during night work. We present a diagram of a sleep-and-light schedule to reduce circadian misalignment in permanent night work, or a rotation between evenings and nights, and give practical advice on how to implement this type of plan.

Indexed as

bright lightcircadian rhythmsmelatoninnight workphase-shiftingsleep

Identifiers

PMID23620685
PMCPMC3630978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.