Evidence map›Paper›PMID 23620600›Full record

ArticleSocial cognitive and affective neuroscience2014

Ventromedial prefrontal cortex and the regulation of physiological arousal.

Sheng Zhang, Sien Hu, Herta H Chao, Jaime S Ide, Xi Luo, Olivia M Farr, Chiang-shan R Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  9. Correlation of sympathetic and parasympathetic nervous system activity during rest and acute stress tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2021
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  13. Comparing three models of arousal in the human brain.Social cognitive and affective neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sheng ZhangDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA sheng.zhang@yale.edu.
Sien HuDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.
Herta H ChaoDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USADepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.
Jaime S IdeDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.
Xi LuoDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.
Olivia M FarrDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.
Chiang-shan R LiDepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USADepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USADepartment of Psychiatry, Department of Medicine, Yale University, New Haven, CT 06519, USA, Department of Medicine, VA Connecticut Healthcare Systems, West Haven, CT 06516, USA, Department of Science and technology, University Federal De Sao Paulo, Sao Jose Dos Campos, Brazil, Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, Rhode Island 02912, USA, Interdepartmental Neuroscience Program, and Department of Neurobiology, Yale University, New Haven, CT 06520, USA.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Cognitive control and cocaine dependence: thalamic noradrenergic processesR01DA023248 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2008 to 2018
$4.0M
Cerebral Correlates of Early Habitual DrinkingR01AA021449 · NIAAA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2013 to 2017
$1.2M
Imaging Cognitive Control in Cocaine DependenceK02DA026990 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2013
$639k
Amygdala Processes and Early Habitual DrinkingR21AA018004 · NIAAA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2010
$383k
Thalamic Processes of Self Control in Cocaine DependenceR21DA026998 · NIDA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2009 to 2010
$373k
Imaging the effects of androgen deprivation therapy on cognitive functions in patR03CA138121 · NCI · YALE UNIVERSITY · PI CHAO, HERTA HUEY-AN · 2009 to 2010
$130k
NCI NIH HHS R03 CA138121NCI NIH HHS R03CA138121NIAAA NIH HHS R21 AA018004NIAAA NIH HHS R21AA018004NIDA NIH HHS K02 DA026990NIDA NIH HHS K02DA026990NIDA NIH HHS R01 DA023248NIDA NIH HHS R01DA023248
6 · The paper itself

Abstract

Neuroimaging studies show a correlation between activity of the ventromedial prefrontal cortex (vmPFC) and skin conductance measurements. However, little is known whether this brain region plays a causal role in regulating physiological arousal. To address this question, we employed Granger causality analysis (GCA) to establish causality between cerebral blood oxygenation level-dependent and skin conductance signals in 24 healthy adults performing a cognitive task during functional magnetic resonance imaging. The results showed that activity of the vmPFC not only negatively correlated with skin conductance level (SCL) but also Granger caused SCL, thus establishing the direction of influence. Importantly, across participants, the strength of Granger causality was negatively correlated to phasic skin conductance responses elicited by external events during the behavioral task. In contrast, activity of the dorsal anterior cingulate cortex positively correlated with SCL but did not show a causal relationship in GCA. These new findings indicate that the vmPFC plays a causal role in regulating physiological arousal. Increased vmPFC activity leads to a decrease in skin conductance. The findings may also advance our understanding of dysfunctions of the vmPFC in mood and anxiety disorders that involve altered control of physiological arousal.

Indexed as

AdultArousalBrainBrain MappingCerebrovascular CirculationCognitionFemaleGalvanic Skin ResponseHumansMagnetic Resonance ImagingMaleNeuropsychological TestsOxygenPrefrontal CortexPsychomotor PerformanceReaction TimeOxygenarousalGranger causalityskin conductanceventromedial prefrontal cortex

Identifiers

PMID23620600
PMCPMC4090954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.