ArticleDrug safety2013
Implementing ecopharmacovigilance in practice: challenges and potential opportunities.
Article in Drug safety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medical Household Waste as a Potential Environmental Hazard: An Ecological and Epidemiological Approach.International journal of environmental research and public health · 2023Pooled it
- Ecopharmacovigilance and Drug Disposal: A Survey of Knowledge, Attitudes and Practices Among Veterinary Healthcare Providers in and Around Gondar City, Ethiopia.Veterinary medicine and science · 2026Article
- Ecopharmacovigilance and pharmacovigilance: an analysis of environment-related reporting in VigiBase.Environmental science and pollution research international · 2026Article
- A comparison of antibiotic resistance reports in pharmacovigilance databases and conventional surveillance across "One Health".Frontiers in public health · 2026Article
- Occurrence of antibacterials, antivirals, and anti-inflammatory pharmaceuticals for COVID-19 treatment as emerging contaminants in the Chinese freshwater environment before, during and after the pandemic: the need for dynamic eco-pharmacovigilance.Environmental health and preventive medicine · 2026Review
- Teaching the true cost of medicines: white paper for a green and sustainable pharmacology curriculum.Frontiers in pharmacology · 2026Review
- A 'One Health' cross-sectional analysis of reports of potential antibiotic resistance cases in international pharmacovigilance databases.Frontiers in public health · 2026Article
- Antibiotic Use in Beekeeping: Implications for Health and Environment from a One-Health Perspective.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Potential spillover effect of eco-directed pharmaceutical disposal on pro-environmental disinfectant use among Chinese residents.Frontiers in public health · 2025Article
- Future Healthcare Workers and Ecopharmacovigilance: Where Do We Stand?Pharmacy (Basel, Switzerland) · 2024Article
- The Earth as a Living Organism: Contribution of Integrative Medicine to the Healing of Our Planet (One Health).Complementary medicine research · 2024Review
- A survey to document toxic hazards in the zone surrounding volcanoes national park, a habitat for mountain gorillas, an endangered wildlife species in Rwanda.Frontiers in veterinary science · 2023Article
- Pharmaceuticals in the Aquatic Environment: A Review on Eco-Toxicology and the Remediation Potential of Algae.International journal of environmental research and public health · 2022Review
- Drug Disposal and Ecopharmacovigilance Practices in the Krowor Municipality, Ghana.Journal of toxicology · 2022Article
- Impact of the COVID-19 pandemic on household disinfectant consumption behaviors and related environmental concerns: A questionnaire-based survey in China.Journal of environmental chemical engineering · 2021Article
- Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study.Antibiotics (Basel, Switzerland) · 2021Article
- Knowledge and Practice on Ecopharmacovigilance and Medicine Storage Amongst Medical and Dental Students in Lalitpur, Nepal.Risk management and healthcare policy · 2021Article
- Article
- Selected Pharmaceuticals in Different Aquatic Compartments: Part II-Toxicity and Environmental Risk Assessment.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ecopharmacovigilance (EPV) is a developing science and it is currently very unclear what it might mean in practice. We have performed a comparison between pharmacovigilance (PV) and EPV and have identified that there are similarities, but also some important differences that must be considered before any practical implementation of EPV. The biggest difference and greatest challenge concerns signal detection in the environment and the difficulty of identifying cause and effect. We reflect on the dramatic vulture decline in Asia, which was caused by the veterinary use of diclofenac, versus the relative difficulty in identifying the specific causes of intersex fish in European rivers. We explore what EPV might mean in practice and have identified that there are some practical measures that can be taken to assess environmental risks across product life cycle, particularly after launch of a new drug, to ensure that our risk assessments and scientific understanding of pharmaceuticals in the environment remain scientifically and ecologically relevant. These include: Tracking environmental risks after launch of the product, via literature monitoring for emerging data on exposure and effects Using Environmental Risk Management Plans (ERMPs) as a centralized resource to assess and manage the risks of a drug throughout its life cycle Further research, testing or monitoring in the environment when a risk is identified Keeping a global EPV perspective Increasing transparency and availability of environmental data for medicinal products. These measures will help to ensure that any significant environmental issues associated with pharmaceuticals in the environment (PIE) are identified in a timely way, and can be managed appropriately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.