ArticleAJNR. American journal of neuroradiology2013
4D CT angiography more closely defines intracranial thrombus burden than single-phase CT angiography.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Dynamic Perviousness Has Predictive Value for Clot Fibrin Content in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Dynamic Perviousness: A Novel Imaging Marker for Predicting Mechanical Thrombectomy Outcomes in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Clot-based time attenuation curve as a novel imaging predictor of mechanical thrombectomy functional outcome in acute ischemia stroke.European radiology · 2024Article
- Dynamic Perviousness Predicts Revascularization Success in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Association between collaterals, cerebral circulation time and outcome after thrombectomy of stroke.Annals of clinical and translational neurology · 2023Article
- RAPID CT Perfusion-Based Relative CBF Identifies Good Collateral Status Better Than Hypoperfusion Intensity Ratio, CBV-Index, and Time-to-Maximum in Anterior Circulation Stroke.AJNR. American journal of neuroradiology · 2022Article
- Deep-Learning-Based Thrombus Localization and Segmentation in Patients with Posterior Circulation Stroke.Diagnostics (Basel, Switzerland) · 2022Article
- Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke.Neuroradiology · 2022Article
- Thrombus Imaging Characteristics and Outcomes in Posterior Circulation Stroke Patients Treated With EVT.Stroke (Hoboken, N.J.) · 2022Article
- Preprocedural Imaging : A Review of Different Radiological Factors Affecting the Outcome of Thrombectomy.Clinical neuroradiology · 2022Review
- Clot Burden Score and Collateral Status and Their Impact on Functional Outcome in Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2021Article
- Collateral Scores in Acute Ischemic Stroke : A retrospective study assessing the suitability of collateral scores as standalone predictors of clinical outcome.Clinical neuroradiology · 2020Article
- Vascular assessment after clipping surgery using four-dimensional CT angiography.Neurosurgical review · 2019Article
- Does Clot Burden Score on Baseline T2*-MRI Impact Clinical Outcome in Acute Ischemic Stroke Treated with Mechanical Thrombectomy?Journal of stroke · 2019Article
- Thrombus Permeability on Dynamic CTA Predicts Good Outcome after Reperfusion Therapy.AJNR. American journal of neuroradiology · 2018Article
- Presence of multi-segment clot sign on dynamic CT angiography: a predictive imaging marker of recanalisation and good outcome in acute ischaemic stroke patients.European radiology · 2018Article
- Slow Collateral Flow Is Associated with Thrombus Extension in Patients with Acute Large-Artery Occlusion.AJNR. American journal of neuroradiology · 2018Article
- Role of time-resolved-CTA in intracranial arteriovenous malformation evaluation at 128-slice CT in comparison with digital subtraction angiography.The neuroradiology journal · 2018Article
- Added value of multiphase CTA imaging for thrombus perviousness assessment.Neuroradiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIn patients with acute stroke, the location and extent of intravascular thrombi correlate with clinical and imaging outcomes and have been used to predict the success of intravenous thrombolysis. We hypothesized that 4D-CTA reconstructed from whole-brain CTP more closely outlines intracranial thrombi than conventional single-phase CTA. MATERIALS AND
methodsSixty-seven patients with anterior circulation occlusion were retrospectively analyzed. For 4D-CTA, temporal maximum intensity projections were calculated that combine all 30 spiral scans of the CTP examination through temporal fusion. Thrombus extent was assessed by a semi-quantitative clot burden score (0-10; in which 0 = complete unilateral anterior circulation occlusion and 10 = patent vasculature). In patients with sufficient collateral flow, the length of the filling defect and corresponding hyperdense middle cerebral artery sign on NCCT were measured.
resultsClot burden on temporal maximum intensity projection (median clot burden score, 7.0; interquartile range, 5.1-8.0) was significantly lower than on single-phase CT angiography (median, 6.0; interquartile range, 4.5-7.0; P < .0001). The length of the hyperdense middle cerebral artery sign (14.30 ± 5.93 mm) showed excellent correlation with the filling defect in the middle cerebral artery on temporal maximum intensity projection (13.40 ± 6.40 mm); this filling defect was larger on single-phase CT angiography (18.08 ± 6.54 mm; P = .043).
conclusionsAs the result of an increased sensitivity for collateral flow, 4D-CTA temporal maximum intensity projection more closely outlines intracranial thrombi than conventional single-phase CT angiography. Our findings can be helpful when planning acute neurointervention. Further research is necessary to validate our data and assess the use of 4D-CTA in predicting response to different recanalization strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.