ArticleBritish journal of cancer2013
Features of cancer in teenagers and young adults in primary care: a population-based nested case-control study.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Interventions to reduce the time to diagnosis of brain tumours.The Cochrane database of systematic reviews · 2020Pooled it
- Is real world evidence influencing practice? A systematic review of CPRD research in NICE guidances.BMC health services research · 2016Pooled it
- Symptomatic diagnosis of cancer of the brain and central nervous system in primary care: a systematic review.Family practice · 2015Pooled it
- Hospital contacts before childhood cancer and the risk of early mortality: a Danish and Swedish population-based cohort study.British journal of cancer · 2026Article
- International variation in child healthcare practices and implications for childhood cancer diagnosis: a scoping review and cross-country clinician survey.European journal of pediatrics · 2026Article
- Identifying children who develop severe chronic kidney disease using primary care records.PloS one · 2025Article
- Health inequalities in cancer care: a literature review of pathways to diagnosis in the United Kingdom.EClinicalMedicine · 2024Review
- Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study.British journal of cancer · 2024Article
- Protocol for the development of a Core Outcome Set (COS) for Adolescents and Young Adults (AYAs) with cancer.BMC cancer · 2024Article
- Breaking barriers: enhancing cancer detection in younger patients by overcoming diagnostic bias in primary care.Frontiers in medicine · 2024Article
- Underlying cancer risk among patients with fatigue and other vague symptoms: a population-based cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2023Article
- Associations between diagnostic time intervals and health-related quality of life, clinical anxiety and depression in adolescents and young adults with cancer: cross-sectional analysis of the BRIGHTLIGHT cohort.British journal of cancer · 2022Article
- Metastatic cancer masquerading as miliary tuberculosis in an immunocompetent young adult.BMJ case reports · 2022Article
- Review
- Article
- Association of Self-reported Presenting Symptoms With Timeliness of Help-Seeking Among Adolescents and Young Adults With Cancer in the BRIGHTLIGHT Study.JAMA network open · 2020Article
- Knowledge of Cancer Risk Factors, Symptoms, and Barriers to Seeking Medical Help among Omani Adolescents.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Cancer diagnoses after emergency GP referral or A&E attendance in England: determinants and time trends in Routes to Diagnosis data, 2006-2015.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Achieving a timely diagnosis for teenagers and young adults with cancer: the ACE "too young to get cancer?" study.BMC cancer · 2019Article
- Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundTeenagers and young adults (TYA, 15-24 years) diagnosed with cancer report repeated visits to primary care before referral. We investigated associations of symptoms and consultation frequency in primary care with TYA cancers.
methodsPopulation-based, case-control study was carried out using data from the Clinical Practice Research Datalink (CPRD). A total of 1064 TYA diagnosed with cancer were matched to 13,206 controls. Symptoms independently associated with specific cancers were identified. Likelihood ratios (LRs) and positive predictive values (PPVs) were calculated.
resultsIn the 3 months before diagnosis, 397 (42.9%) cases consulted > or =4 times vs 593(11.5%) controls (odds ratio (OR): 12.1; 95% CI: 9.7, 15.1), yielding a PPV for any cancer of 0.018%. The LR of lymphoma with a head/neck mass was 434 (95% CI: 60, 3158), with a PPV of 0.5%. Corresponding figures in other cancers included - LR of leukaemia with lymphadenopathy (any site): 29 (95% CI: 8, 112), PPV 0.015%; LR of CNS tumour with seizure: 56 (95% CI: 19, 163), PPV 0.024%; and LR of sarcoma with lump/mass/swelling: 79 (95% CI: 24, 264), PPV 0.042%.
conclusionTeenagers and young adults with cancer consulted more frequently than controls in the 3 months before diagnosis. Primary care features of cancer match secondary care reports, but were of very low risk; nonetheless, some features increased the likelihood of cancer substantially and should be taken seriously when assessing TYA.
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