ArticleRNA biology2013
Functional characterization of Upf1 targets in Schizosaccharomyces pombe.
Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- NMD-mediated control of Tor influences adaptation to nutrient and temperature conditions inbioRxiv : the preprint server for biology · 2026Article
- Article
- Sensing of H2O2-induced oxidative stress by the UPF factor complex is crucial for activation of catalase-3 expression in Neurospora.PLoS genetics · 2023Article
- The Substrates of Nonsense-Mediated mRNA Decay inG3 (Bethesda, Md.) · 2018Article
- Nonsense-mediated RNA decay--a switch and dial for regulating gene expression.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.G3 (Bethesda, Md.) · 2014Article
- Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.PLoS genetics · 2014Article
- The translational landscape of fission-yeast meiosis and sporulation.Nature structural & molecular biology · 2014Article
- In vivo determination of direct targets of the nonsense-mediated decay pathway in Drosophila.G3 (Bethesda, Md.) · 2014Article
- Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress.RNA biology · 2014Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Nonsense-mediated mRNA decay (NMD) is a highly conserved mechanism of mRNA degradation. NMD eliminates mRNAs containing premature termination codons (PTCs), preventing the production of truncated proteins with possible deleterious effects. However, there is mounting evidence that NMD factors, like Upf1, Upf2 and Upf3, participate in general regulation of gene expression, affecting the expression of genes lacking PTCs. We have used the fission yeast Schizosaccharomyces pombe to identify mRNAs directly regulated by NMD. Using a combination of genetic and biochemical approaches, we have defined a population of fission yeast mRNAs specifically regulated by Upf1. We show that other components of the Upf complex, Upf2 and Upf3, are required for binding of Upf1 to its RNA targets and for the proper response of fission yeast to oxidative stress. Finally, we investigated the physiological importance of this phenomenon, and demonstrate that the Upf1-dependent downregulation of some of its direct targets is necessary for normal resistance to oxidative stress.
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