ArticleVirus research2013
Genetic susceptibility to feline infectious peritonitis in Birman cats.
Article in Virus research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature.American journal of human genetics · 2020Pooled it
- Low incidence of feline infectious peritonitis in rehomed shelter cats with known feline coronavirus status: a cohort study of 767 cats.Journal of feline medicine and surgery · 2026Article
- Applying Supervised Machine Learning to Effusion Analysis for the Diagnosis of Feline Infectious Peritonitis.Bioengineering (Basel, Switzerland) · 2026Article
- Deciphering Viral Replication Dynamics in Feline Infectious Peritonitis: A Quantitative Approach.Viruses · 2025Article
- Endogenous Endophthalmitis Caused by Prototheca Microalga in Birman Cat, Spain.Emerging infectious diseases · 2025Article
- Immune Responses and Pathogenesis following Experimental SARS-CoV-2 Infection in Domestic Cats.Viruses · 2023Article
- Complex Feline Disease Mapping Using a Dense Genotyping Array.Frontiers in veterinary science · 2022Article
- More Than a Moggy; A Population Genetics Analysis of the United Kingdom's Non-Pedigree Cats.Genes · 2021Article
- Review
- The Population Diversity of Candidate Genes for Resistance/Susceptibility to Coronavirus Infection in Domestic Cats: An Inter-Breed Comparison.Pathogens (Basel, Switzerland) · 2021Article
- A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats.PloS one · 2021Article
- Article
- The Effect of Natural Feline Coronavirus Infection on the Host Immune Response: A Whole-Transcriptome Analysis of the Mesenteric Lymph Nodes in Cats with and without Feline Infectious Peritonitis.Pathogens (Basel, Switzerland) · 2020Article
- Immunocytochemistry of mesenteric lymph node fine-needle aspirates in the diagnosis of feline infectious peritonitis.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Applications and efficiencies of the first cat 63K DNA array.Scientific reports · 2018Article
- Diagnosis of feline infectious peritonitis: Update on evidence supporting available tests.Journal of feline medicine and surgery · 2018Review
- Toxoplasma gondii seroprevalence varies by cat breed.PloS one · 2017Article
- Clinical and laboratory features of cats with feline infectious peritonitis--a retrospective study of 231 confirmed cases (2000-2010).Journal of feline medicine and surgery · 2016Article
- Natural resistance to experimental feline infectious peritonitis virus infection is decreased rather than increased by positive genetic selection.Veterinary immunology and immunopathology · 2016Article
- Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis.Advances in virus research · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal. Therefore, we sought evidence for genetic susceptibility to FIP using feline high density single nucleotide polymorphism (SNP) arrays in a genome-wide association study (GWAS). Birman cats were chosen for GWAS because they are highly inbred and suffer a high incidence of FIP. DNA from 38 Birman cats that died of FIP and 161 healthy cats from breeders in Denmark and USA were selected for genotyping using 63K SNPs distributed across the feline genome. Danish and American Birman cats were closely related and the populations were therefore combined and analyzed in two manners: (1) all cases (FIP) vs. all controls (healthy) regardless of age, and (2) cases 1½ years of age and younger (most susceptible) vs. controls 2 years of age and older (most resistant). GWAS of the second cohort was most productive in identifying significant genome-wide associations between case and control cats. Four peaks of association with FIP susceptibility were identified, with two being identified on both analyses. Five candidate genes ELMO1, RRAGA, TNFSF10, ERAP1 and ERAP2, all relevant to what is known about FIP virus pathogenesis, were identified but no single association was fully concordant with the disease phenotype. Difficulties in doing GWAS in cats and interrogating complex genetic traits were discussed.
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