ArticleThe Clinical journal of pain2014
Experimental pain responses support peripheral and central sensitization in patients with unilateral shoulder pain.
Article in The Clinical journal of pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effect of Central Sensitization on Steroid Injection Response in Patients With Shoulder Pain Secondary to Rotator Cuff Lesion
Investigation of the Effect of Pre-treatment Central Sensitization Severity on Steroid Injection Results in Rotator Cuff-induced Shoulder Pain
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- The combined effects of manual therapy and exercise on pain and related disability for individuals with nonspecific neck pain: A systematic review with meta-analysis.The Journal of manual & manipulative therapy · 2023Pooled it
- Psychometric properties of quantitative sensory testing in healthy and patients with shoulder pain: A systematic review.Journal of musculoskeletal & neuronal interactions · 2023Pooled it
- The effect of mindfulness combined with exercise compared with a self-management guide on measures of nervous system sensitivity in individuals with chronic pain: a pilot randomised control trial.Irish journal of medical science · 2025Trial
- Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial.The Journal of manual & manipulative therapy · 2020Trial
- Immediate changes in pressure pain sensitivity after thoracic spinal manipulative therapy in patients with subacromial impingement syndrome: A randomized controlled study.Manual therapy · 2015Trial
- The comparative effects of spinal and peripheral thrust manipulation and exercise on pain sensitivity and the relation to clinical outcome: a mechanistic trial using a shoulder pain model.The Journal of orthopaedic and sports physical therapy · 2015Trial
- Pain sensitivity subgroups in individuals with spine pain: potential relevance to short-term clinical outcome.Physical therapy · 2014Trial
- Suprathreshold heat pain response predicts activity-related pain, but not rest-related pain, in an exercise-induced injury model.PloS one · 2014Trial
- Sleep disturbance in patients undergoing shoulder surgery: a current concepts review.JSES reviews, reports, and techniques · 2026Review
- Effects of resistance exercises on rotator cuff muscle mechanical characteristics in shoulders with and without rotator cuff tears.PloS one · 2026Article
- Article
- The impact of central sensitization-related symptoms on subacromial steroid injection outcomes in patients with subacromial impingement syndrome: an observational study.The Korean journal of pain · 2025Article
- Reliability of Pressure Pain Threshold (PPT) and Conditioned Pain Modulation (CPM) in Participants with and without Chronic Shoulder Pain.Healthcare (Basel, Switzerland) · 2024Article
- Laryngeal and Global Somatosensation in Primary Muscle Tension Dysphonia.Journal of voice : official journal of the Voice Foundation · 2024Article
- Biopsychosocial contributors to irritability in individuals with shoulder or low back pain.The Journal of manual & manipulative therapy · 2024Article
- Effects of acupuncture on pain and function in patients with subacromial impingement syndrome: A randomized sham-controlled trial.Integrative medicine research · 2024Article
- Test-Retest Reliability of Pain Sensitivity Measures in Individuals with Shoulder Pain.Journal of pain research · 2024Article
- A cross-sectional observational study comparing individuals with a symptomatic full-thickness rotator cuff tear with age-matched controls.JSES international · 2024Article
- Differences in Trapezius Muscle H-Reflex between Asymptomatic Subjects and Symptomatic Shoulder Pain Subjects.Sensors (Basel, Switzerland) · 2023Article
- Relationship of Healthy Building Determinants With Musculoskeletal Disorders of the Extremities: A Systematic Review.Cureus · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe aims of this study were to (1) examine the pattern of experimental pain responses in the affected and nonaffected extremities in patients with shoulder pain and (2) explore the intraindividual association between sensitization states derived from experimental pain testing.
methodsExperimental pain responses from 58 patients with shoulder pain (17 women, aged 18 to 52 y) were compared with those from 56 age-matched and sex-matched pain-free volunteers (16 women, aged 21 to 58 y). Experimental pain responses included pressure pain threshold (PPT), thermal pain threshold and tolerance, and suprathreshold heat pain response. Comparisons were made between the affected and nonaffected extremities of clinical participants and the average response of extremities in control participants. Peripheral and central sensitization indexes were computed for clinical participants using standardized scores and percentile cutoffs on the basis of the data from the control sample. Experimental pain responses in clinical participants observed beyond the 25th and 75th percentile of control sample responses were used for investigation of intraindividual association of sensitization states.
resultsPPT at the acromion and masseter on the affected side of clinical participants were diminished compared with that on their nonaffected side (P<0.015). Bilateral sensitivity in clinical participants was noted for PPT at the acromion and suprathreshold heat pain response (P<0.015). Peripheral and central sensitization indexes demonstrated that individuals with shoulder pain present with variable patterns of peripheral and central sensitization.
conclusionsCollectively, experimental pain responses supported peripheral and central sensitization in response to pressure and thermal stimuli. No clear association was made between individuals exhibiting peripheral or central sensitization, thus suggesting heterogeneity in pain processing in this clinical population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.