ArticleCancer epidemiology2013
Childhood passive smoke exposure is associated with adult head and neck cancer.
Article in Cancer epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Passive smoking and risk of head and neck cancer: a systematic review and meta-analysis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025Pooled it
- Prevalence and prognostic impact of HPV, EBV, and HIV in head and neck squamous cell carcinoma in the Brazilian Amazon cohort.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival.medRxiv : the preprint server for health sciences · 2025Article
- Diagnostic accuracy of HPV16 early antigen serology for HPV-driven oropharyngeal cancer is independent of age and sex.International journal of cancer · 2024Article
- Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review.Frontiers in public health · 2024Review
- Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma.Medical sciences (Basel, Switzerland) · 2023Review
- A risk prediction model for head and neck cancers incorporating lifestyle factors, HPV serology and genetic markers.International journal of cancer · 2023Article
- Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders.European journal of dentistry · 2023Article
- Trend of passive smoking and associated factors in Iranian children and adolescents: the CASPIAN studies.BMC public health · 2022Article
- Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study.Aging · 2020Article
- Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Review
- Survey Mode and Rates of Smoke-free Homes and Support for Smoking Bans Among Single Parents in the United States in 2010-2011 and 2014-2015.Survey practice · 2018Article
- Tobacco Use and Smoke Exposure in Children: New Trends, Harm, and Strategies to Improve Health Outcomes.Current allergy and asthma reports · 2017Review
- Relationship of Lifetime Exposure to Tobacco, Alcohol and Second Hand Tobacco Smoke with Upper aero-digestive tract cancers in India: a Case-Control Study with a Life-Course PerspectiveAsian Pacific journal of cancer prevention : APJCP · 2017Article
- A bibliometric analysis on tobacco regulation investigators.BioData mining · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionPassive smoke is carcinogenic but its association with head and neck squamous cell carcinoma (HNSCC) is uncertain.
methodsWe conducted a case-control study of childhood passive smoke exposure (CPSE) and HNSCC in 858 cases and 806 frequency-matched controls using an interviewer-administered questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression controlling for adult smoking in the total study population, and in never-smokers only (184 cases and 415 controls). CPSE was also studied in oropharyngeal separately from other HNSCC using polytomous logistic regression.
resultsCPSE was associated with HNSCC (OR, 1.28; 95% CI, 1.01-1.63) after controlling for adult smoking and other factors. This association was similar in magnitude, although not statistically significant, among subjects who never smoked as adults (OR, 1.19, 95% CI, 0.80-1.76). CPSE was associated more strongly with oropharyngeal cancer (a HNSCC subtype commonly associated with human papillomavirus (HPV) infection) than with HNSCC at non-oropharyngeal sites (OR, 2.02; 95% CI, 1.01-4.06, N=52 cases vs. OR, 1.04; 95% CI, 0.68-1.60, N=132 cases; P-for-heterogeneity=0.08).
conclusionsData from this large US-based case control study suggest a role for CPSE in HNSCC etiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.