ArticleMicrobiology (Reading, England)2013
Refinement of the Listeria monocytogenes σB regulon through quantitative proteomic analysis.
Article in Microbiology (Reading, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Complex interplay of riboregulatory mechanisms at theJournal of bacteriology · 2026Article
- Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025Review
- Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures.Frontiers in genetics · 2025Article
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- Complete Genome Sequences of Three Listeria monocytogenes Bacteriophage Propagation Strains.Microbiology resource announcements · 2021Article
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- Transcriptomic and Phenotypic Analyses of the Sigma B-Dependent Characteristics and the Synergism between Sigma B and Sigma L inMicroorganisms · 2020Article
- Redefining the Clostridioides difficile σmSphere · 2020Article
- Cross Talk between SigB and PrfA in Listeria monocytogenes Facilitates Transitions between Extra- and Intracellular Environments.Microbiology and molecular biology reviews : MMBR · 2019Review
- TheFrontiers in microbiology · 2018Article
- Chitinase Expression in Listeria monocytogenes Is Influenced byApplied and environmental microbiology · 2017Article
- Home Alone: Elimination of All but One Alternative Sigma Factor inFrontiers in microbiology · 2017Article
- Stochastic and Differential Activation of σFrontiers in microbiology · 2017Article
- Complete Circular Genome Sequence and Temperature Independent Adaptation to Anaerobiosis ofFrontiers in microbiology · 2017Article
- Resilience in the Face of Uncertainty: Sigma Factor B Fine-Tunes Gene Expression To Support Homeostasis in Gram-Positive Bacteria.Applied and environmental microbiology · 2016Review
- An advanced bioinformatics approach for analyzing RNA-seq data reveals sigma H-dependent regulation of competence genes in Listeria monocytogenes.BMC genomics · 2016Article
- Contributions of σ(B) and PrfA to Listeria monocytogenes salt stress under food relevant conditions.International journal of food microbiology · 2014Article
- How Listeria monocytogenes organizes its surface for virulence.Frontiers in cellular and infection microbiology · 2014Review
- Listeria monocytogenes: survival and adaptation in the gastrointestinal tract.Frontiers in cellular and infection microbiology · 2014Review
- Regulatory network features in Listeria monocytogenes-changing the way we talk.Frontiers in cellular and infection microbiology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
σ(B) is an alternative σ factor that regulates stress response and virulence genes in the foodborne pathogen Listeria monocytogenes. To gain further insight into σ(B)-dependent regulatory mechanisms in L. monocytogenes, we (i) performed quantitative proteomic comparisons between the L. monocytogenes parent strain 10403S and an isogenic ΔsigB mutant and (ii) conducted a meta-analysis of published microarray studies on the 10403S σ(B) regulon. A total of 134 genes were found to be significantly positively regulated by σ(B) at the transcriptomic level with >75 % of these genes preceded by putative σ(B)-dependent promoters; 21 of these 134 genes were also found to be positively regulated by σ(B) through proteomics. In addition, 15 proteins were only found to be positively regulated by σ(B) through proteomics analyses, including Lmo1349, a putative glycine cleavage system protein. The lmo1349 gene is preceded by a 5' UTR that functions as a glycine riboswitch, which suggests regulation of glycine metabolism by σ(B) in L. monocytogenes. Herein, we propose a model where σ(B) upregulates pathways that facilitate biosynthesis and uptake of glycine, which may then activate this riboswitch. Our data also (i) identified a number of σ(B)-dependent proteins that appear to be encoded by genes that are co-regulated by multiple transcriptional regulators, in particular PrfA, and (ii) found σ(B)-dependent genes and proteins to be overrepresented in the 'energy metabolism' role category, highlighting contributions of the σ(B) regulon to L. monocytogenes energy metabolism as well as a role of PrfA and σ(B) interaction in regulating aspects of energy metabolism in L. monocytogenes.
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