ArticleScience (New York, N.Y.)2013
The cross-bridge spring: can cool muscles store elastic energy?
Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion.Journal of biomechanical engineering · 2016Trial
- Temperature affects the torque-velocity relationship of the ankle plantar flexor muscles.Scientific reports · 2025Article
- Nanometer scale difference in myofilament lattice structure of muscle alters muscle function in a spatially explicit model.PLoS computational biology · 2025Article
- Moth resonant mechanics are tuned to wingbeat frequency and energetic demands.Proceedings. Biological sciences · 2024Article
- Mechanism of elastic energy storage of honey bee abdominal muscles under stress relaxation.Journal of insect science (Online) · 2023Article
- The hawkmoth wingbeat is not at resonance.Biology letters · 2022Article
- A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice.Biophysical journal · 2021Article
- Dimensional analysis of spring-wing systems reveals performance metrics for resonant flapping-wing flight.Journal of the Royal Society, Interface · 2021Article
- Article
- Localization of the Elastic Proteins in the Flight Muscle ofInternational journal of molecular sciences · 2020Article
- Nanometer-scale structure differences in the myofilament lattice spacing of two cockroach leg muscles correspond to their different functions.The Journal of experimental biology · 2020Article
- Indirect actuation reduces flight power requirements inJournal of the Royal Society, Interface · 2019Article
- Passive force and viscoelastic properties of single fibers in human aging muscles.European journal of applied physiology · 2019Article
- A Spatially Explicit Model Shows How Titin Stiffness Modulates Muscle Mechanics and Energetics.Integrative and comparative biology · 2018Article
- Synchrotron Radiation X-ray Diffraction Techniques Applied to Insect Flight Muscle.International journal of molecular sciences · 2018Review
- Active Viscoelasticity of Sarcomeres.Frontiers in robotics and AI · 2018Review
- Fish optimize sensing and respiration during undulatory swimming.Nature communications · 2016Article
- Contribution of elastic tissues to the mechanics and energetics of muscle function during movement.The Journal of experimental biology · 2016Review
- Elastic proteins in the flight muscle of Manduca sexta.Archives of biochemistry and biophysics · 2015Article
- In-vivo measurement of muscle tension: dynamic properties of the MC sensor during isometric muscle contraction.Sensors (Basel, Switzerland) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Muscles not only generate force. They may act as springs, providing energy storage to drive locomotion. Although extensible myofilaments are implicated as sites of energy storage, we show that intramuscular temperature gradients may enable molecular motors (cross-bridges) to store elastic strain energy. By using time-resolved small-angle x-ray diffraction paired with in situ measurements of mechanical energy exchange in flight muscles of Manduca sexta, we produced high-speed movies of x-ray equatorial reflections, indicating cross-bridge association with myofilaments. A temperature gradient within the flight muscle leads to lower cross-bridge cycling in the cooler regions. Those cross-bridges could elastically return energy at the extrema of muscle lengthening and shortening, helping drive cyclic wing motions. These results suggest that cross-bridges can perform functions other than contraction, acting as molecular links for elastic energy storage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.