ArticleBioPsychoSocial medicine2013
Psychosocial and cognitive function in children with nephrotic syndrome: association with disease and treatment variables.
Article in BioPsychoSocial medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Patient and caregiver perspectives on mental health in children and adolescents with chronic kidney disease.Clinical kidney journal · 2025Article
- Assessment of health-related quality of life of children with idiopathic nephrotic syndrome and their caregivers in China.Health and quality of life outcomes · 2024Article
- Increased behavioural problems associated with corticosteroid use in children with nephrotic syndrome: a Southeast Asian perspective.Singapore medical journal · 2023Article
- Long-term complications in patients with childhood-onset nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Psychosocial supports within pediatric nephrology practices: A pediatric nephrology research consortium survey.PloS one · 2023Article
- Quality of life in children with nephrotic syndrome: a cross-sectional study using Hindi version of PedsQL 4.0 Generic Core Scales.Clinical and experimental nephrology · 2022Article
- Psychological aspects in children and parents of children with chronic kidney disease and their families.Clinical and experimental pediatrics · 2022Article
- Younger age and early puberty are associated with cognitive function decline in children with Cushing disease.Clinical endocrinology · 2022Article
- Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review.International journal of nephrology and renovascular disease · 2022Article
- Albuminuria as a risk factor for mild cognitive impairment and dementia-what is the evidence?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Review
- Worsening anasarca on a child with severe steroid-dependent nephrotic syndrome without proteinuria: Answers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Impact of steroids and steroid-sparing agents on quality of life in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Behavioural abnormalities in children with new-onset nephrotic syndrome receiving corticosteroid therapy: results of a prospective longitudinal study.Pediatric nephrology (Berlin, Germany) · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate possible differences in emotional/behavioral problems and cognitive function in children with nephrotic syndrome compared to healthy controls and to examine the effect of disease-specific and steroid treatment-specific characteristics on the abovementioned variables.
methodsForty-one patients with nephrotic syndrome (23 boys, age range: 4.4-15.2 years) and 42 sex- and age-matched healthy control subjects (20 boys, age range: 4.1-13.4 years) were enrolled in the study. Disease (severity, age of diagnosis, duration) and steroid treatment (total duration, present methylprednisolone dose and duration of present dose) data were collected. In order to assess children's emotional/behavioral problems, the Child Behavior Checklist was administered. The Wechsler Intelligence Scale for Children - Third Edition was administered to assess Full-Scale, Verbal, and Performance intelligence quotient (IQ) scores.
resultsThe patients presented with more internalizing problems (P = 0.015), including withdrawal (P = 0.012) and somatic complaints (P = 0 .011), but not more anxiety/depression or externalizing problems. A significant association was found between severity of disease and somatic complaints (P = 0.017) as well as externalizing problems (P = 0.030). Years of illness were significantly more in those presenting with abnormal anxiety/depression (P = 0.011). Duration of steroid medication was significantly higher among those presenting with abnormal anxiety/depression (P = 0.011) and externalizing problems (P = 0.039). IQ was not associated significantly with disease or steroid treatment variables.
conclusionsPsychosocial factors and outcomes may be important correlates of children's nephrotic syndrome and potential targets of thorough assessment and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.