Evidence map›Paper›PMID 23618075›Full record

ArticleItalian journal of pediatrics2013

Serum hepcidin: indication of its role as an "acute phase" marker in febrile children.

Lydia Kossiva, Alexandra Soldatou, Dimitrios I Gourgiotis, Lamprini Stamati, Charalampos Tsentidis

Abstract readComparative Study
In one paragraph

Article in Italian journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. The diagnostic value of serum hepcidin in acute appendicitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Applied value of monitoring serum hepcidin in differential diagnosis of infection versus tumor fevers.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lydia KossivaSecond Department of Pediatrics P&A Kyriakou Children's Hospital, Medical School, Athens University, Athens, Greece. lydiakossiva@hotmail.com
Alexandra Soldatou
Dimitrios I Gourgiotis
Lamprini Stamati
Charalampos Tsentidis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepcidin is classified as a type II acute phase protein; its production is a component of the innate immune response to infections.

objectiveTo evaluate the alterations of serum hepcidin in children during and following an acute febrile infection. MATERIALS AND

methods22 children with fever of acute onset (< 6 hours) admitted to the 2nd Department of Pediatrics-University of Athens. Based on clinical and laboratory findings our sample formed two groups: the viral infection group (13 children) and the bacterial infection group (9 children). Hepcidin, ferritin and serum iron measurements were performed in all subjects.

resultsSerum hepcidin values did not differ notably between children with viral and bacterial infection, but a significant reduction of hepcidin was noted in both groups post-infection.

conclusionOur study provides clinical pediatric data on the role of hepcidin in the face of an acute infection. In our sample of children, hepcidin was found to rise during the acute infection and fall post-infection.

Indexed as

Acute DiseaseAcute-Phase ProteinsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial InfectionsBiomarkersChildChild, PreschoolFemaleFerritinsFeverHepcidinsHospitals, PediatricHospitals, UniversityHumansInfantAcute-Phase ProteinsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBiomarkersFerritinsHAMP protein, humanHepcidinsIron

Identifiers

PMID23618075
PMCPMC3660274

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.